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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1bl7SB4Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1bl7SB4Mitogen-activated protein kinase 14/1.000
1bmkSB5Mitogen-activated protein kinase 14/0.610
1bl6SB6Mitogen-activated protein kinase 14/0.587
2zazGK1Mitogen-activated protein kinase 14/0.555
1ouy094Mitogen-activated protein kinase 14/0.553
3l8sBFFMitogen-activated protein kinase 14/0.540
1m7qDQOMitogen-activated protein kinase 14/0.536
1ouk084Mitogen-activated protein kinase 14/0.517
3gc7B45Mitogen-activated protein kinase 14/0.509
2zb0GK3Mitogen-activated protein kinase 14/0.503
3fmlFMLMitogen-activated protein kinase 14/0.498
3fsfFSSMitogen-activated protein kinase 14/0.495
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
2k62ITLFatty acid-binding protein, liver/0.487
1yqj6NPMitogen-activated protein kinase 14/0.486
1hvhQ82Gag-Pol polyprotein3.4.23.160.484
1oz1FPHMitogen-activated protein kinase 14/0.484
1zyjBI5Mitogen-activated protein kinase 14/0.483
3fmn530Mitogen-activated protein kinase 14/0.482
1ywrLI9Mitogen-activated protein kinase 14/0.479
3opdHIEHeat shock protein 83/0.479
4dlj6RGMitogen-activated protein kinase 14/0.479
4eh60ONMitogen-activated protein kinase 14/0.477
5f0a1FBcGMP-dependent protein kinase, putative/0.477
1ove358Mitogen-activated protein kinase 14/0.476
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.475
2j7t274Serine/threonine-protein kinase 102.7.11.10.474
2vwpNDPGlucose 1-dehydrogenase/0.474
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.474
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.470
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.470
3flyFLYMitogen-activated protein kinase 14/0.470
1merDMQGag-Pol polyprotein3.4.23.160.469
3ha85JZMitogen-activated protein kinase 14/0.469
4jx1CAMCamphor 5-monooxygenase1.14.15.10.469
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
3flzFLZMitogen-activated protein kinase 14/0.468
3s4qNK0Mitogen-activated protein kinase 14/0.468
1sh9RITGag-Pol polyprotein3.4.23.160.467
3flsFLSMitogen-activated protein kinase 14/0.467
3gfeP37Mitogen-activated protein kinase 14/0.467
3w551FMMitogen-activated protein kinase 12.7.11.240.467
4eh50OMMitogen-activated protein kinase 14/0.467
4jx1CAHCamphor 5-monooxygenase1.14.15.10.467
1m17AQ4Epidermal growth factor receptor2.7.10.10.466
2ewaSB2Mitogen-activated protein kinase 14/0.466
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.465
3upjU03Gag-Pol polyprotein/0.465
3qbfJHGGag-Pol polyprotein3.4.23.160.464
3qp0NI8Gag-Pol polyprotein3.4.23.160.464
4jrnANPRhoptry kinase family protein/0.464
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.463
3lxiCAMCytochrome P450/0.463
3zpuM8BGag-Pol polyprotein3.4.23.160.463
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.462
1w7h3IPMitogen-activated protein kinase 14/0.462
3ekx1UNGag-Pol polyprotein3.4.23.160.462
1k6tXN1Gag-Pol polyprotein3.4.23.160.461
3flq891Mitogen-activated protein kinase 14/0.461
3fskRO6Mitogen-activated protein kinase 14/0.461
4o0wADNAurora kinase A2.7.11.10.461
1hsgMK1Gag-Pol polyprotein/0.460
1zz2B11Mitogen-activated protein kinase 14/0.460
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
1odw0E8Gag-Pol polyprotein3.4.23.160.459
1xl2189Gag-Pol polyprotein3.4.23.160.459
2bpy3INGag-Pol polyprotein3.4.23.160.459
3fmh533Mitogen-activated protein kinase 14/0.459
4ewqMWLMitogen-activated protein kinase 14/0.459
5eypLOCTubulin beta chain/0.459
1lcbDHFThymidylate synthase/0.458
2gn9UPGUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.458
2qnqQN3Gag-Pol polyprotein3.4.23.160.458
3igoANPCalmodulin-domain protein kinase 1, putative/0.458
3qj5022Alcohol dehydrogenase class-31.1.1.10.458
1jld0PPGag-Pol polyprotein/0.457
1npa3NHGag-Pol polyprotein3.4.23.160.457
1npwLGZGag-Pol polyprotein3.4.23.160.457
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.457
3h03UBPGlutamate receptor 2/0.457
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
1c6zROCProtease/0.456
1iwiCAMCamphor 5-monooxygenase1.14.15.10.456
2ckeIQUDeath-associated protein kinase 2/0.456
2pwcG3GGag-Pol polyprotein3.4.23.160.456
3mvl38PMitogen-activated protein kinase 14/0.456
3nwq2NCGag-Pol polyprotein3.4.23.160.456
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.456
4f630S7Fibroblast growth factor receptor 1/0.456
4jrvKJVEpidermal growth factor receptor2.7.10.10.456
1hvkA79Gag-Pol polyprotein/0.455
1w84L12Mitogen-activated protein kinase 14/0.455
2ca0PXICytochrome P450 monooxygenase PikC/0.455
2hs2017Protease/0.455
3flwFLWMitogen-activated protein kinase 14/0.455
3fr8NDPKetol-acid reductoisomerase, chloroplastic1.1.1.860.455
3nxe2NCProtease/0.455
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
1dz6CAMCamphor 5-monooxygenase1.14.15.10.454
1hiiC20Gag-Pol polyprotein/0.454
1t7i017Gag-Pol polyprotein3.4.23.160.454
3fln3FNMitogen-activated protein kinase 14/0.454
4nks2M2Fibroblast growth factor receptor 1/0.454
1k6pXN3Gag-Pol polyprotein3.4.23.160.453
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.453
3sls77DDual specificity mitogen-activated protein kinase kinase 12.7.12.20.453
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
1phePIYCamphor 5-monooxygenase1.14.15.10.452
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.452
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.452
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
1sguMK1Gag-Pol polyprotein3.4.23.160.451
2qd7065Gag-Pol polyprotein3.4.23.160.451
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.451
3kfr3TLGag-Pol polyprotein/0.451
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.451
3zptM8YGag-Pol polyprotein3.4.23.160.451
4g3qUD1Bifunctional protein GlmU/0.451
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
1dz8CAMCamphor 5-monooxygenase1.14.15.10.450
1ida0POGag-Pol polyprotein3.4.23.470.450
1idb0DOGag-Pol polyprotein/0.450
1mesDMPGag-Pol polyprotein3.4.23.160.450
1t87CAMCamphor 5-monooxygenase1.14.15.10.450
1wbk568Pol protein/0.450
2a1mCAMCamphor 5-monooxygenase1.14.15.10.450
2b56UTPRNA editing complex protein MP57/0.450
2xyeCXGGag-Pol polyprotein/0.450
3d20017Gag-Pol polyprotein3.4.23.160.450
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.450
3pt6SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.450
3t54ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.450
4f640S8Fibroblast growth factor receptor 1/0.450
1bv7XV6Gag-Pol polyprotein3.4.23.160.449
1dmpDMQGag-Pol polyprotein3.4.23.160.449
1nooCAHCamphor 5-monooxygenase1.14.15.10.449
2qhcAB1Protease/0.449
2r5q1UNGag-Pol polyprotein/0.449
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.449
3fwfCAMCamphor 5-monooxygenase1.14.15.10.449
3l63CAMCamphor 5-monooxygenase1.14.15.10.449
3nj0PYVAbscisic acid receptor PYL2/0.449
3qn8NI7Gag-Pol polyprotein3.4.23.160.449
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.449
1wvxBD4Death-associated protein kinase 12.7.11.10.448
2bpz3INGag-Pol polyprotein3.4.23.160.448
2pym1UNGag-Pol polyprotein3.4.23.160.448
2qbnCAMCamphor 5-monooxygenase1.14.15.10.448
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.448
3q5iANPProtein kinase, putative/0.448
3qihNI7Gag-Pol polyprotein3.4.23.160.448
4b99R4LMitogen-activated protein kinase 72.7.11.240.448
4dqb017Gag-Pol polyprotein/0.448
4ye3G04Gag-Pol polyprotein3.4.23.160.448
1c6x3INProtease/0.447
1svlADPLarge T antigen3.6.40.447
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.447
2bpw1INGag-Pol polyprotein3.4.23.160.447
2hb3GRLProtease/0.447
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.447
3hllI45Mitogen-activated protein kinase 14/0.447
3jw2017Gag-Pol polyprotein3.4.23.160.447
3p6oETGCamphor 5-monooxygenase1.14.15.10.447
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4c9pCAMCytochrome P450/0.447
4g3rCAMCamphor 5-monooxygenase1.14.15.10.447
1a8g2Z4Gag-Pol polyprotein3.4.23.160.446
1ajxAH1Gag-Pol polyprotein3.4.23.160.446
1hpoUNIGag-Pol polyprotein3.4.23.160.446
1lcbTMPThymidylate synthase/0.446
1yrdCAMCamphor 5-monooxygenase1.14.15.10.446
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.446
2fdd385Pol protein/0.446
2ieo017Protease/0.446
2v1xADPATP-dependent DNA helicase Q13.6.4.120.446
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.446
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.446
3qrmNK7Gag-Pol polyprotein3.4.23.160.446
3uvqFS8Mitogen-activated protein kinase 14/0.446
4eh70OOMitogen-activated protein kinase 14/0.446
4jq8KJ8Epidermal growth factor receptor2.7.10.10.446
4njt017Protease/0.446
1b6mPI6Gag-Pol polyprotein3.4.23.160.445
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.445
1nzfUPGDNA beta-glucosyltransferase/0.445
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
1sbgIM1Gag-Pol polyprotein/0.445
2a4fAAUV-1 protease/0.445
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.445
2qblCAMCamphor 5-monooxygenase1.14.15.10.445
2r43G3GGag-Pol polyprotein3.4.23.160.445
2uxzHI1Gag-Pol polyprotein3.4.23.160.445
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.445
3a7hATPSerine/threonine-protein kinase 242.7.11.10.445
3cktYDPGag-Pol polyprotein3.4.23.160.445
3kfs3TLGag-Pol polyprotein/0.445
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.445
3t113T1Gag-Pol polyprotein3.4.23.160.445
4e5yNDPGDP-L-fucose synthase1.1.1.2710.445
4k4p3TLGag-Pol polyprotein/0.445
4nka2K7Fibroblast growth factor receptor 1/0.445
1bdqIM1Gag-Pol polyprotein3.4.23.160.444
2acxANPG protein-coupled receptor kinase 62.7.11.160.444
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.444
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.444
2j0lANPFocal adhesion kinase 12.7.10.20.444
2qi6MZ8Gag-Pol polyprotein/0.444
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.444
3ggpNADPrephenate dehydrogenase/0.444
3kf03TLGag-Pol polyprotein/0.444
3qaiXNNKetohexokinase/0.444
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
4a6bQG8Gag-Pol polyprotein3.4.23.160.444
4l03NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.444
1ajvNMBGag-Pol polyprotein3.4.23.160.443
1meuDMPGag-Pol polyprotein3.4.23.160.443
2avvMK1Gag-Pol polyprotein3.4.23.160.443
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2hc0AB2Protease/0.443
2p3a3TLPol protein/0.443
2qi4MZ6Gag-Pol polyprotein/0.443
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.443
3i7eDJRGag-Pol polyprotein/0.443
3ndwRITGag-Pol polyprotein3.4.23.160.443
3pwrROCGag-Pol polyprotein3.4.23.160.443
3q92XNBKetohexokinase/0.443
3saa77FProtease/0.443
4dtaADNAPH(2'')-Id/0.443
4ic7ANPMitogen-activated protein kinase 72.7.11.240.443
4jr3KJREpidermal growth factor receptor2.7.10.10.443
4l4eCAMCamphor 5-monooxygenase1.14.15.10.443
4loqSB4Mitogen-activated protein kinase 14/0.443
5eoxADPType 4 fimbrial biogenesis protein PilM/0.443
1bdrIM1Gag-Pol polyprotein3.4.23.160.442
1hvsA77Gag-Pol polyprotein/0.442
1iiq0ZRGag-Pol polyprotein3.4.23.160.442
1mrwK57Gag-Pol polyprotein3.4.23.160.442
1qbsDMPGag-Pol polyprotein3.4.23.160.442
1sduMK1Gag-Pol polyprotein3.4.23.160.442
1t88CAMCamphor 5-monooxygenase1.14.15.10.442
1yt9OISGag-Pol polyprotein/0.442
2aidTHKGag-Pol polyprotein3.4.23.160.442
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.442
2hs1017Protease/0.442
2npnSAMPutative cobalamin synthesis related protein/0.442
2r3wG3GGag-Pol polyprotein3.4.23.160.442
2xclANPPhosphoribosylamine--glycine ligase/0.442
3mpt1GKMitogen-activated protein kinase 14/0.442
3nu9478Gag-Pol polyprotein3.4.23.160.442
3oxv478Gag-Pol polyprotein3.4.23.160.442
3sabF78Protease/0.442
3vfa031Gag-Pol polyprotein3.4.23.160.442
4a6cQG9Gag-Pol polyprotein3.4.23.160.442
4eh3NARMitogen-activated protein kinase 14/0.442
4fklCK2Cyclin-dependent kinase 22.7.11.220.442
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.442
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4hyp1A1DNA gyrase subunit B/0.442
4l06NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
4s32ANPMitogen-activated protein kinase 12.7.11.240.442
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.441
1rf9DBRCamphor 5-monooxygenase1.14.15.10.441
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2itqITQEpidermal growth factor receptor2.7.10.10.441
2q631UNGag-Pol polyprotein3.4.23.160.441
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.441
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.441
3aidARQGag-Pol polyprotein3.4.23.160.441
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3ggu017Gag-Pol polyprotein3.4.23.160.441
3nu5478Gag-Pol polyprotein3.4.23.160.441
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.441
3w33W19Epidermal growth factor receptor2.7.10.10.441
3zsh469Mitogen-activated protein kinase 14/0.441
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4g3pUD1Bifunctional protein GlmU/0.441
4jq7KJQEpidermal growth factor receptor2.7.10.10.441
4l4cCAMCamphor 5-monooxygenase1.14.15.10.441
1ec3MS3Gag-Pol polyprotein3.4.23.160.440
1hxwRITGag-Pol polyprotein/0.440
1w8cN69Cyclin-dependent kinase 22.7.11.220.440
2cd8PXICytochrome P450 monooxygenase PikC/0.440
2cvxDGTRibonucleoside-diphosphate reductase large chain 11.17.4.10.440
2jkoBIJFocal adhesion kinase 12.7.10.20.440
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3qrsNK8Gag-Pol polyprotein3.4.23.160.440
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.440
4joa3DKALK tyrosine kinase receptor2.7.10.10.440
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.440
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440