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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1bduDURThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1bduDURThymidylate synthase/1.000
1aobDDUThymidylate synthase/0.842
2vetUMPThymidylate synthase/0.699
1bidUMPThymidylate synthase/0.667
1jmgUMPThymidylate synthase/0.511
1jmiUMPThymidylate synthase/0.498
1jmfUMPThymidylate synthase/0.489
2g89UMPThymidylate synthase/0.473
1jmhUMPThymidylate synthase/0.470
2g8aUMPThymidylate synthase/0.470
3bgxTMPThymidylate synthase/0.468
1njbUMPThymidylate synthase/0.466
1lcbTMPThymidylate synthase/0.464
1tsyUMPThymidylate synthase/0.463
1njaDCMThymidylate synthase/0.453
1bp6UMPThymidylate synthase/0.451
1njdUMPThymidylate synthase/0.448
1tsxUMPThymidylate synthase/0.448
1vzaUMPThymidylate synthase/0.448
2g86UMPThymidylate synthase/0.448
1vzbUMPThymidylate synthase/0.443
1tsvUMPThymidylate synthase/0.441