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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1b8yIN7Stromelysin-13.4.24.17

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1b8yIN7Stromelysin-13.4.24.171.000
1caqDPSStromelysin-13.4.24.170.662
1cizDPSStromelysin-13.4.24.170.549
3tskQEGMacrophage metalloelastase3.4.24.650.530
1g4kHQQStromelysin-13.4.24.170.517
2wo9068Macrophage metalloelastase3.4.24.650.516
1uttCP8Macrophage metalloelastase3.4.24.650.515
4i03L88Macrophage metalloelastase3.4.24.650.513
2woa576Macrophage metalloelastase3.4.24.650.510
3lilEEAMacrophage metalloelastase3.4.24.650.507
2wo8077Macrophage metalloelastase3.4.24.650.505
3ljgEEFMacrophage metalloelastase3.4.24.650.500
4gr0R4BMacrophage metalloelastase3.4.24.650.496
4a7b3W4Collagenase 33.4.240.491
4gqlR47Macrophage metalloelastase3.4.24.650.491
1ztq033Collagenase 33.4.240.488
3kry3KRCollagenase 33.4.240.488
3i7i518Collagenase 33.4.240.483
3o2x3O2Collagenase 33.4.240.481
4a7b3W5Collagenase 33.4.240.481
4gr8R4CMacrophage metalloelastase3.4.24.650.481
3kec3KECollagenase 33.4.240.478
3likEEGMacrophage metalloelastase3.4.24.650.475
2ovx4MRMatrix metalloproteinase-93.4.24.350.473
1hy7MBSStromelysin-13.4.24.170.467
2yig5ELCollagenase 33.4.240.467
1slnINHStromelysin-13.4.24.170.463
1c8tTR1Stromelysin-13.4.24.170.456
1zvxFINNeutrophil collagenase3.4.24.340.447
1g05BBHStromelysin-13.4.24.170.442