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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1b5tFAD5,10-methylenetetrahydrofolate reductase1.5.1.20

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1b5tFAD5,10-methylenetetrahydrofolate reductase1.5.1.201.000
3fsuFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.586
1zp4FAD5,10-methylenetetrahydrofolate reductase1.5.1.200.583
1zp3FAD5,10-methylenetetrahydrofolate reductase1.5.1.200.570
2fmoFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.542
3fstFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.529
1zptFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.528
1zrqFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.527
3apyFADMethylenetetrahydrofolate reductase/0.489