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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1b15NAEAlcohol dehydrogenase1.1.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1b15NAEAlcohol dehydrogenase1.1.1.11.000
1b16NAQAlcohol dehydrogenase1.1.1.10.814
3rj5NADAlcohol dehydrogenase1.1.1.10.682
3rj9NADAlcohol dehydrogenase1.1.1.10.634
1sbyNADAlcohol dehydrogenase1.1.1.10.585
1mg5NAIAlcohol dehydrogenase1.1.1.10.575
5jlaNADPutative short-chain dehydrogenase/reductase/0.548
1iy8NADLevodione reductase/0.547
5lc1NADL-threonine 3-dehydrogenase/0.547
3a4vNADNDP-sugar epimerase/0.538
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.535
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.532
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.530
4gh5NADShort-chain dehydrogenase/reductase SDR/0.524
2wsbNADGalactitol dehydrogenase/0.522
4dc1NDPPutative ketoacyl reductase1.3.10.522
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.521
3wdsNADNADH-dependent quinuclidinone reductase/0.521
1b14NADAlcohol dehydrogenase1.1.1.10.519
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.519
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.518
3ak4NADNADH-dependent quinuclidinone reductase/0.517
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.517
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.516
3uxyNADShort-chain dehydrogenase/reductase SDR/0.515
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.511
3qrwNDPPutative ketoacyl reductase1.3.10.509
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.508
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.505
1pr9NAPL-xylulose reductase1.1.1.100.505
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.505
1zemNADXylitol dehydrogenase/0.504
2wdzNADGalactitol dehydrogenase/0.504
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.502
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.501
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.501
4yaiNAIC alpha-dehydrogenase/0.500
1x7hNDPPutative ketoacyl reductase1.3.10.499
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.499
1wntNAPL-xylulose reductase1.1.1.100.498
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.498
1w4zNAPPutative ketoacyl reductase1.3.10.496
1ae1NAPTropinone reductase 1/0.495
2p5uNADUDP-glucose 4-epimerase/0.495
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.495
3toxNAPPutative oxidoreductase/0.495
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.493
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.486
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.486
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.485
4yagNAIC alpha-dehydrogenase/0.484
1ipeNDPTropinone reductase 21.1.1.2360.483
3w8dNAD3-hydroxybutyrate dehydrogenase/0.482
3w8fNAD3-hydroxybutyrate dehydrogenase/0.482
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.481
4j7uNAPSepiapterin reductase1.1.1.1530.481
2yutNAPPutative short-chain oxidoreductase/0.480
4qecNAPElxO/0.479
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.478
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.477
4bmvNAPShort-chain dehydrogenase/0.477
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
1xkqNDPUncharacterized protein/0.476
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.475
3sx2NADUncharacterized protein/0.473
1snyNAPLD36273p/0.472
1x7gNAPPutative ketoacyl reductase1.3.10.472
3a1nNADNDP-sugar epimerase/0.472
3d3wNAPL-xylulose reductase1.1.1.100.472
3gy0NAPNAD(P)-dependent oxidoreductase/0.472
2yy7NADL-threonine dehydrogenase/0.471
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.471
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.471
1xg5NAPDehydrogenase/reductase SDR family member 11/0.470
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.470
3ajrNADNDP-sugar epimerase/0.470
4wlvNADMalate dehydrogenase, mitochondrial1.1.1.370.470
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.469
2dteNAIGlucose 1-dehydrogenase related protein/0.469
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.469
1n5dNDPCarbonyl reductase [NADPH] 1/0.468
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.467
3p19NDPPutative blue fluorescent protein/0.467
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.467
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.467
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.466
3wmxNADNAD dependent epimerase/dehydratase/0.466
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.466
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
3lqfNADGalactitol dehydrogenase/0.465
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.464
3sjuNDPKeto reductase/0.464
3w8eNAD3-hydroxybutyrate dehydrogenase/0.462
4wluNADMalate dehydrogenase, mitochondrial1.1.1.370.462
1z7eATPBifunctional polymyxin resistance protein ArnA/0.461
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.461
4fn4NADShort chain dehydrogenase/0.461
4impNDPPolyketide synthase extender modules 3-4/0.460
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.458
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.458
5idwNAPShort-chain dehydrogenase/reductase SDR/0.458
3aw9NADNAD-dependent epimerase/dehydratase/0.457
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.456
3ggoNAIPrephenate dehydrogenase/0.456
3l77NJPShort-chain alcohol dehydrogenase/0.456
3s55NADPutative short-chain dehydrogenase/reductase/0.456
3vdqNAD3-hydroxybutyrate dehydrogenase/0.456
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.454
3f1kNAPUncharacterized oxidoreductase YciK10.453
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.453
4hwkNAPSepiapterin reductase1.1.1.1530.453
2bd0NAPSepiapterin reductase/0.452
2jahNDPClavaldehyde dehydrogenase/0.452
5jydNADShort chain dehydrogenase/0.452
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.451
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.451
1ybaNADD-3-phosphoglycerate dehydrogenase1.1.1.950.449
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.448
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.448
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.448
4nbwNADShort-chain dehydrogenase/reductase SDR/0.448
1ybmNAPUncharacterized protein At5g02240/0.447
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.447
1g1aNADdTDP-glucose 4,6-dehydratase/0.446
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.446
1geeNADGlucose 1-dehydrogenase1.1.1.470.445
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
2hjrAPRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase/0.445
4j7xNAPSepiapterin reductase1.1.1.1530.444
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.443
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.442
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.442
5dcyNAPIridoid synthase1.3.1.990.442
1i3lNADUDP-glucose 4-epimerase/0.441
1kvrNADUDP-glucose 4-epimerase5.1.3.20.441
2g5cNADPrephenate dehydrogenase/0.441
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
1ie3NADMalate dehydrogenase/0.440
1sowNADL-lactate dehydrogenase1.1.1.270.440
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.440
4qedNAPElxO/0.440
5jy1NADPutative short-chain dehydrogenase/reductase/0.440