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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1az1ALRAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1az1ALRAldose reductase1.1.1.211.000
2nvdITBAldose reductase1.1.1.210.490
1pqc444Oxysterols receptor LXR-beta/0.488
1dhfFOLDihydrofolate reductase1.5.1.30.472
2aclL05Oxysterols receptor LXR-alpha/0.472
1s3uTQDDihydrofolate reductase1.5.1.30.466
1osvCHCBile acid receptor/0.465
3n0hTOPDihydrofolate reductase1.5.1.30.457
2ipw2CLAldose reductase1.1.1.210.453
1mvtDTMDihydrofolate reductase1.5.1.30.450
1pd9CO4Dihydrofolate reductase1.5.1.30.447
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.444
3s3vTOPDihydrofolate reductase1.5.1.30.444
3fx4FX4Alcohol dehydrogenase [NADP(+)]1.1.1.20.441
4q0kGA3Phytohormone-binding protein/0.440