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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ay0TPPTransketolase 12.2.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1ay0TPPTransketolase 12.2.1.11.000
1tkbN1TTransketolase 12.2.1.10.594
1ngsTPPTransketolase 12.2.1.10.574
3uptTPPTransketolase/0.546
1tkaN3TTransketolase 12.2.1.10.542
1itzTPPTransketolase, chloroplastic2.2.1.10.530
1tkcM6TTransketolase 12.2.1.10.523
1trkTPPTransketolase 12.2.1.10.520
1rp7TZDPyruvate dehydrogenase E1 component1.2.4.10.498
2r5nTPPTransketolase 1/0.493
3lq4TDPPyruvate dehydrogenase E1 component1.2.4.10.490
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.487
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.485
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.478
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.478
3rimTPPTransketolase2.2.1.10.454
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.446
2ieaTDPPyruvate dehydrogenase E1 component1.2.4.10.442
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
4q71FADBifunctional protein PutA/0.440