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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1axwMTXThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1axwMTXThymidylate synthase/1.000
1jtqLY3Thymidylate synthase/0.669
1dnaCB3Thymidylate synthase/0.614
1kceCB3Thymidylate synthase/0.571
1fwmCB3Thymidylate synthase/0.561
1aiqCB3Thymidylate synthase/0.552
1dduCB3Thymidylate synthase/0.547
1tduCB3Thymidylate synthase/0.537
1zprCB3Thymidylate synthase/0.528
2bbqPFGThymidylate synthase/0.527
1trgCB3Thymidylate synthase/0.526
1kzjCB3Thymidylate synthase/0.520
2ftoCB3Thymidylate synthase/0.511
1nceCB3Thymidylate synthase/0.506
3bgxMEFThymidylate synthase/0.506
2tscCB3Thymidylate synthase/0.505
1jtuLYBThymidylate synthase/0.502
1tysDHFThymidylate synthase/0.502
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.500
1ju6LYAThymidylate synthase2.1.1.450.495
4fqsLYAThymidylate synthase ThyA/0.491
1bq1CB3Thymidylate synthase/0.486
1kziTHGThymidylate synthase/0.486
4gevCB3Thymidylate synthase/0.486
1jutLYDThymidylate synthase/0.483
4foxD16Thymidylate synthase ThyA/0.482
4knzCB3Thymidylate synthase/0.477
1hvyD16Thymidylate synthase2.1.1.450.476
1an5CB3Thymidylate synthase/0.474
1synF89Thymidylate synthase/0.470
3uwlFOZThymidylate synthase/0.467
1f4fTP3Thymidylate synthase/0.466
3bhlTHGThymidylate synthase/0.463
4ez8DHFThymidylate synthase2.1.1.450.462
1jujLYAThymidylate synthase2.1.1.450.456
3bhrTHGThymidylate synthase/0.456
2kceD16Thymidylate synthase/0.455
1tsdF89Thymidylate synthase/0.452
1ci7CB3Thymidylate synthase2.1.1.450.451
4isk1JYThymidylate synthase/0.451
2aazCB3Thymidylate synthase2.1.1.450.450
1f28F89Thymidylate synthase2.1.1.450.449
4o7uTHFThymidylate synthase/0.445
4fogC2FThymidylate synthase ThyA/0.444
4eilCB3Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443