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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1arhPPDAspartate aminotransferase2.6.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1arhPPDAspartate aminotransferase2.6.1.11.000
1argPPDAspartate aminotransferase2.6.1.10.542
1x28PGUAspartate aminotransferase2.6.1.10.518
1ahgTYR_PLPAspartate aminotransferase2.6.1.10.515
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.500
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.488
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.485
4rkdKETAminotransferase/0.466
1cq7PY5Aspartate aminotransferase2.6.1.10.463
1mapKETAspartate aminotransferase, mitochondrial2.6.1.10.463
1cq6PY4Aspartate aminotransferase2.6.1.10.462
1ascNPLAspartate aminotransferase2.6.1.10.461
1cq8PY6Aspartate aminotransferase2.6.1.10.459
3qpg3QPAspartate aminotransferase2.6.1.10.456
4dbc3QPAspartate aminotransferase2.6.1.10.455
1akaPLPAspartate aminotransferase, mitochondrial2.6.1.10.452
4iah1DXAlr2278 protein/0.446
1c7oPPGHemolysin/0.445
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
2eixFADNADH-cytochrome b5 reductase/0.441
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4jtqNAPAldo-keto reductase family 1 member C2/0.441