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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ah3TOLAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1ah3TOLAldose reductase1.1.1.211.000
2pdlTOLAldose reductase1.1.1.210.658
2fzdTOLAldose reductase1.1.1.210.651
2fzbTOLAldose reductase1.1.1.210.611
2pdh47DAldose reductase1.1.1.210.565
1zuaTOLAldo-keto reductase family 1 member B101.1.10.563
4wevSUZAldo-keto reductase family 1 member B101.1.10.539
2pdfZSTAldose reductase1.1.1.210.524
5liu388Aldo-keto reductase family 1 member B101.1.10.514
1ry0PG2Aldo-keto reductase family 1 member C3/0.497
2f3815MAldo-keto reductase family 1 member C3/0.497
1s36CEIObelin/0.496
1ry8RUTAldo-keto reductase family 1 member C3/0.494
1z4iUMP5'(3')-deoxyribonucleotidase, mitochondrial3.1.30.493
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.491
1uhjCZBAequorin-2/0.486
4mqt2CUMuscarinic acetylcholine receptor M2/0.484
2fzjDH3Dihydrofolate reductase1.5.1.30.482
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.482
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.482
1ej3CZHAequorin-2/0.481
4dbuBT9Aldo-keto reductase family 1 member C3/0.480
1el4CTZObelin/0.477
4fam0SZAldo-keto reductase family 1 member C3/0.477
1t40ID5Aldose reductase1.1.1.210.476
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
1uhhCZPAequorin-2/0.475
1qv0CZHObelin/0.474
3a1l2CCCytochrome P450/0.474
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.474
2duxZSTAldose reductase1.1.1.210.473
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.473
2vcmM11Isopenicillin N synthase1.21.3.10.472
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.472
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.472
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.471
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.470
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.469
2bjsACVIsopenicillin N synthase1.21.3.10.469
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.469
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.469
4nqgCZHMitrocomin/0.469
1jf0CZHObelin/0.466
2vbpVB1Isopenicillin N synthase1.21.3.10.466
1blzACVIsopenicillin N synthase1.21.3.10.465
2i16LDTAldose reductase1.1.1.210.465
1qiqACCIsopenicillin N synthase1.21.3.10.464
3ug8IMNAldo-keto reductase family 1 member C3/0.464
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.464
1qv1CZHObelin/0.463
4ey6GNTAcetylcholinesterase3.1.1.70.463
1ohkCOPDihydrofolate reductase1.5.1.30.462
1xf0ASDAldo-keto reductase family 1 member C3/0.462
2i17LDTAldose reductase1.1.1.210.462
3htjETEbrA repressor/0.462
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.462
1bk0ACVIsopenicillin N synthase1.21.3.10.461
2xufTZ4Acetylcholinesterase3.1.1.70.461
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.461
3mb9ZSTAldose reductase1.1.1.210.461
3ugrIMNAldo-keto reductase family 1 member C3/0.461
1kmsLIHDihydrofolate reductase1.5.1.30.460
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
3m0iZSTAldose reductase1.1.1.210.460
3r6iJMSAldo-keto reductase family 1 member C3/0.460
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.460
4n1fCZHObelin/0.460
1yc2NADNAD-dependent protein deacylase 2/0.459
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
1jf2CZHObelin/0.458
2duzZSTAldose reductase1.1.1.210.458
2fs4PZ1Renin3.4.23.150.458
2g263LGRenin3.4.23.150.458
2nvcITAAldose reductase1.1.1.210.458
2pzn393Aldose reductase1.1.1.210.457
4mrxCZHObelin/0.457
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.456
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
2hvnZSTAldose reductase1.1.1.210.456
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.456
3t0kDCQSulfide-quinone reductase/0.456
4gca2X9Aldose reductase1.1.1.210.456
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.455
2dv0ZSTAldose reductase1.1.1.210.455
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
4a16H34Acetylcholinesterase3.1.1.70.455
1odnAPVIsopenicillin N synthase1.21.3.10.454
1s7gNADNAD-dependent protein deacylase 2/0.454
1z8962PAldose reductase1.1.1.210.454
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.454
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.453
4gtt7TQGeranylgeranyl transferase type-2 subunit beta2.5.1.600.453
1sl9CZHObelin/0.452
2hv5ZSTAldose reductase1.1.1.210.452
4bfuZVUPantothenate kinase2.7.1.330.452
1qtiGNTAcetylcholinesterase3.1.1.70.451
1z3n3NAAldose reductase1.1.1.210.451
2xuiTZ5Acetylcholinesterase3.1.1.70.451
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.451
3wqmB29Diterpene synthase3.1.7.80.451
2pdxZSTAldose reductase1.1.1.210.450
2vrjNCWBeta-glucosidase A3.2.1.210.450
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.450
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.450
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.450
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.449
4h7c10HAldo-keto reductase family 1 member C3/0.449
5cc9DDFDihydrofolate reductase1.5.1.30.449
4u150HKMuscarinic acetylcholine receptor M3/0.449
1ieiZESAldose reductase1.1.1.210.448
1pq6965Oxysterols receptor LXR-beta/0.448
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2pdj393Aldose reductase1.1.1.210.448
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.448
3lenZSTAldose reductase1.1.1.210.448
4kebFOLDihydrofolate reductase1.5.1.30.448
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
2iki388Aldose reductase1.1.1.210.447
3v94WYQPhosphodiesterase/0.447
3zkuHCVIsopenicillin N synthase1.21.3.10.447
4e0u0MVCyclic dipeptide N-prenyltransferase/0.447
1zq5E04Aldo-keto reductase family 1 member C3/0.446
3g6zA7TRenin3.4.23.150.446
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.446
3mc5393Aldose reductase1.1.1.210.446
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.446
4dbw511Aldo-keto reductase family 1 member C3/0.446
1hb3SCVIsopenicillin N synthase1.21.3.10.445
1oc1ASVIsopenicillin N synthase1.21.3.10.445
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.445
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.445
2vqqTFGHistone deacetylase 43.5.1.980.445
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.445
3n0hTOPDihydrofolate reductase1.5.1.30.445
3p5sAVUCD38 molecule/0.445
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2xuhTZ4Acetylcholinesterase3.1.1.70.444
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.444
3hywDCQSulfide-quinone reductase/0.444
4fa30SLAldo-keto reductase family 1 member C3/0.444
1ekoI84Aldose reductase1.1.1.210.443
1obnASVIsopenicillin N synthase1.21.3.10.443
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2b04CHOPhospholipase A2, major isoenzyme3.1.1.40.443
2getCOKPantothenate kinase2.7.1.330.443
3g5eQ74Aldose reductase1.1.1.210.443
4boeCLRJapanin/0.443
4pnmNU1Tankyrase-22.4.2.300.443
1pqc444Oxysterols receptor LXR-beta/0.442
2vz0D64Pteridine reductase/0.442
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.442
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.442
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.442
4jpg1OXPyruvate kinase PKM2.7.1.400.442
4kxjP34Nucleoprotein/0.442
1pwlBFIAldose reductase1.1.1.210.441
2q153MRBeta-secretase 13.4.23.460.441
3g70A5TRenin3.4.23.150.441
3g72A6TRenin3.4.23.150.441
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.441
3t8xT8XT-cell surface glycoprotein CD1b/0.441
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4yu153NAldose reductase1.1.1.210.441
3qakUKAAdenosine receptor A2a/0.441
1hfrMOTDihydrofolate reductase1.5.1.30.440
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.440
1t41ID5Aldose reductase1.1.1.210.440
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.440
2g7yMO9Cathepsin S3.4.22.270.440
3lboLDTAldose reductase1.1.1.210.440
3ld5LDTAldose reductase1.1.1.210.440
3nn6HNK6-hydroxy-L-nicotine oxidase/0.440
4arbC57Acetylcholinesterase3.1.1.70.440