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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ae1NAPTropinone reductase 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ae1NAPTropinone reductase 1/1.000
4j7xNAPSepiapterin reductase1.1.1.1530.554
1ipeNDPTropinone reductase 21.1.1.2360.551
4j7uNAPSepiapterin reductase1.1.1.1530.541
1snyNAPLD36273p/0.532
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.529
4hwkNAPSepiapterin reductase1.1.1.1530.520
3p19NDPPutative blue fluorescent protein/0.516
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.511
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.508
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.507
1x7gNAPPutative ketoacyl reductase1.3.10.506
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.501
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.501
1xg5NAPDehydrogenase/reductase SDR family member 11/0.500
3sjuNDPKeto reductase/0.500
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.500
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.499
4qecNAPElxO/0.499
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.497
4dc1NDPPutative ketoacyl reductase1.3.10.497
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.497
1x7hNDPPutative ketoacyl reductase1.3.10.495
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.495
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.494
1w4zNAPPutative ketoacyl reductase1.3.10.494
3l77NJPShort-chain alcohol dehydrogenase/0.494
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.493
5idwNAPShort-chain dehydrogenase/reductase SDR/0.493
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.490
4bmvNAPShort-chain dehydrogenase/0.489
2jahNDPClavaldehyde dehydrogenase/0.488
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.487
3qrwNDPPutative ketoacyl reductase1.3.10.486
4qedNAPElxO/0.486
1n5dNDPCarbonyl reductase [NADPH] 1/0.484
1xkqNDPUncharacterized protein/0.484
3gy0NAPNAD(P)-dependent oxidoreductase/0.484
5jlaNADPutative short-chain dehydrogenase/reductase/0.484
1oaaNAPSepiapterin reductase1.1.1.1530.482
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.481
2bd0NAPSepiapterin reductase/0.478
1pr9NAPL-xylulose reductase1.1.1.100.477
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.473
3tn7NJPShort-chain alcohol dehydrogenase/0.471
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.470
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.470
3f1kNAPUncharacterized oxidoreductase YciK10.470
2yutNAPPutative short-chain oxidoreductase/0.469
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.468
3toxNAPPutative oxidoreductase/0.468
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.462
3lqfNADGalactitol dehydrogenase/0.460
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.457
1wntNAPL-xylulose reductase1.1.1.100.454
2dteNAIGlucose 1-dehydrogenase related protein/0.452
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.448
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.447
3d3wNAPL-xylulose reductase1.1.1.100.447
1rwbNADGlucose 1-dehydrogenase1.1.1.470.446
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.445
3ai3NDPNADPH-sorbose reductase/0.445
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.445
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.444
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.444
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.444
4gh5NADShort-chain dehydrogenase/reductase SDR/0.444
1g6kNADGlucose 1-dehydrogenase1.1.1.470.443
3u4cNDPNADPH-dependent reductase BacG/0.443
3vdqNAD3-hydroxybutyrate dehydrogenase/0.443
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.442
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.442
4fn4NADShort chain dehydrogenase/0.441