scPDB - Distribution of Binding site Similarity values of 1a9c entry / Site 10

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1a9c	GTP	GTP cyclohydrolase 1	3.5.4.16

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1a9c	GTP	GTP cyclohydrolase 1	3.5.4.16	1.000
4du6	GTP	GTP cyclohydrolase 1	/	0.563
1a8r	GTP	GTP cyclohydrolase 1	3.5.4.16	0.522
1n3r	GTP	GTP cyclohydrolase 1	3.5.4.16	0.511
1n3s	GTP	GTP cyclohydrolase 1	3.5.4.16	0.494
1kyx	CRM	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.477
2a57	CRM	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.477
3qt6	2P0	Mevalonate diphosphate decarboxylase	/	0.473
1n95	HFP	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	/	0.472
1n95	HFP	Protein farnesyltransferase subunit beta	2.5.1.58	0.472
3eu5	GBO	Protein farnesyltransferase subunit beta	2.5.1.58	0.472
1nup	NMN	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3	/	0.470
2x06	NAD	L-sulfolactate dehydrogenase	/	0.470
2z7h	GG3	Geranylgeranyl pyrophosphate synthase	/	0.469
4qfy	DCP	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	3.1.5	0.468
2fxu	BID	Actin, alpha skeletal muscle	/	0.467
2yd0	BES	Endoplasmic reticulum aminopeptidase 1	3.4.11	0.465
3wqm	B29	Diterpene synthase	3.1.7.8	0.465
1odj	GMP	Purine nucleoside phosphorylase	/	0.464
1xva	SAM	Glycine N-methyltransferase	2.1.1.20	0.462
2iib	C5P	Alpha-2,3/2,6-sialyltransferase/sialidase	/	0.462
2fw3	BUI	Carnitine O-palmitoyltransferase 2, mitochondrial	2.3.1.21	0.461
3h3r	14H	Collagen type IV alpha-3-binding protein	/	0.461
1ds7	FMN	Oxygen-insensitive NAD(P)H nitroreductase	/	0.460
1xe6	5FP	Plasmepsin-2	3.4.23.39	0.460
3q9b	B3N	Acetylpolyamine amidohydrolase	/	0.457
1yki	FMN	Oxygen-insensitive NAD(P)H nitroreductase	/	0.456
2iko	7IG	Renin	3.4.23.15	0.456
2ojt	UBA	Glutamate receptor ionotropic, kainate 1	/	0.455
3h3t	16H	Collagen type IV alpha-3-binding protein	/	0.455
4dpt	AGS	Mevalonate diphosphate decarboxylase	/	0.455
1n95	FTH	Protein farnesyltransferase subunit beta	2.5.1.58	0.453
1wur	8DG	GTP cyclohydrolase 1	/	0.453
1x1c	SAH	C-20 methyltransferase	/	0.453
3gwd	NAP	Cyclohexanone monooxygenase	/	0.453
3jsx	CC2	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.452
2a2c	ADP	N-acetylgalactosamine kinase	2.7.1.157	0.451
2vyq	FAD	Ferredoxin--NADP reductase	1.18.1.2	0.451
3v2u	ATP	Protein GAL3	/	0.450
4bby	FAD	Alkyldihydroxyacetonephosphate synthase, peroxisomal	2.5.1.26	0.450
4g09	0VD	Histidinol dehydrogenase	/	0.450
3sqx	ANP	ATP-dependent RNA helicase MSS116, mitochondrial	3.6.4.13	0.449
4bft	ZVT	Pantothenate kinase	2.7.1.33	0.449
4qg0	DUT	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	3.1.5	0.449
1gg5	E09	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.448
1h63	FMN	Pentaerythritol tetranitrate reductase	/	0.448
1w34	FAD	Ferredoxin--NADP reductase	1.18.1.2	0.448
2ejz	SAH	Diphthine synthase	/	0.448
3fst	FAD	5,10-methylenetetrahydrofolate reductase	1.5.1.20	0.448
3tr0	5GP	Guanylate kinase	/	0.448
3uzw	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.448
4eag	ATP	5'-AMP-activated protein kinase subunit gamma-1	/	0.448
1h50	FMN	Pentaerythritol tetranitrate reductase	/	0.447
1ozp	ACO	Mycothiol acetyltransferase	2.3.1.189	0.446
1x1b	SAH	C-20 methyltransferase	/	0.446
2a59	LMZ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.446
1cf3	FAD	Glucose oxidase	1.1.3.4	0.445
2fut	H1S	Heparin and heparin-sulfate lyase	/	0.445
2uxo	TAC	HTH-type transcriptional regulator TtgR	/	0.445
2vet	UMP	Thymidylate synthase	/	0.445
2xck	MH4	3-phosphoinositide-dependent protein kinase 1	2.7.11.1	0.445
3fhx	PLP	Pyridoxal kinase	2.7.1.35	0.445
3hyg	099	A disintegrin and metalloproteinase with thrombospondin motifs 5	3.4.24	0.445
3jun	AJD	Phenazine biosynthesis protein A/B	/	0.445
4ohw	ATP	Protein clpf-1	/	0.445
1iol	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.444
1rr6	IMH	Purine nucleoside phosphorylase	2.4.2.1	0.444
1vbi	NAD	Malate/L-lactate dehydrogenase family protein	/	0.444
3bgs	DIH	Purine nucleoside phosphorylase	2.4.2.1	0.444
3e6e	DCS	Alanine racemase	/	0.444
3e32	ED2	Protein farnesyltransferase subunit beta	2.5.1.58	0.443
3slk	NDP	Polyketide synthase extender module 2	/	0.443
4jnk	ZHK	L-lactate dehydrogenase A chain	1.1.1.27	0.443
4m83	ERY	Oleandomycin glycosyltransferase	2.4.1	0.443
1b5e	DCM	Deoxycytidylate 5-hydroxymethyltransferase	2.1.2.8	0.442
2a2d	ANP	N-acetylgalactosamine kinase	2.7.1.157	0.442
2a92	NAI	L-lactate dehydrogenase	/	0.442
2i7p	ACO	Pantothenate kinase 3	2.7.1.33	0.442
3dys	5GP	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.442
3dys	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.442
4rvg	TYD	D-mycarose 3-C-methyltransferase	/	0.442
1c7o	PPG	Hemolysin	/	0.441
1ejb	INJ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.441
1gpn	HUB	Acetylcholinesterase	3.1.1.7	0.441
1oxo	IK2	Aspartate aminotransferase, mitochondrial	2.6.1.1	0.441
2rlc	CHD	Choloylglycine hydrolase	3.5.1.24	0.441
3ihg	VAK	Aklavinone 12-hydroxylase RdmE	/	0.441
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.441
5dp2	NAP	CurF	/	0.441
1fcb	FMN	Cytochrome b2, mitochondrial	1.1.2.3	0.440
1fml	RTL	Retinol dehydratase	/	0.440
1je1	GMP	Purine nucleoside phosphorylase	/	0.440
1qor	NDP	Quinone oxidoreductase 1	/	0.440
1rft	PXM	Pyridoxal kinase	2.7.1.35	0.440
2q1w	NAD	Putative nucleotide sugar epimerase/ dehydratase	/	0.440
2xve	FAD	Putative flavin-containing monooxygenase	/	0.440
3dy8	5GP	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.440