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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1a4zNADAldehyde dehydrogenase, mitochondrial1.2.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1a4zNADAldehyde dehydrogenase, mitochondrial1.2.1.31.000
4i8pNADAminoaldehyde dehydrogenase 1/0.590
4pt0NADAldehyde dehydrogenase/0.545
3hazNADBifunctional protein PutA/0.531
4zz7NADMethylmalonate-semialdehyde dehydrogenase/0.491
3rhqNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.487
1uxvNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.480
1ez0NAPNADP-dependent fatty aldehyde dehydrogenase1.2.1.40.470
5ez4NADBetaine-aldehyde dehydrogenase/0.466
1wnbNAIGamma-aminobutyraldehyde dehydrogenase1.2.1.190.464
5dp2NAPCurF/0.450
1f4fTP3Thymidylate synthase/0.443
5dibNADBetaine-aldehyde dehydrogenase/0.441