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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1a2bGSPTransforming protein RhoA

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1a2bGSPTransforming protein RhoA/1.000
2gcpGSPRho-related GTP-binding protein RhoC/0.620
1cxzGSPTransforming protein RhoA/0.607
1kmqGNPTransforming protein RhoA/0.606
1m7bGTPRho-related GTP-binding protein RhoE/0.600
1s1cGNPTransforming protein RhoA/0.586
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.579
4js0GNPCell division control protein 42 homolog/0.570
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.569
3a58GNPGTP-binding protein RHO1/0.556
3kz1GSPTransforming protein RhoA/0.555
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.547
3oesGNPGTPase RhebL1/0.547
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.547
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.541
1e96GTPRas-related C3 botulinum toxin substrate 1/0.538
3eg5GNPCell division control protein 42 homolog/0.538
4mitGTPRho-related protein racC/0.537
1zbdGTPRas-related protein Rab-3A/0.536
4xoiGTPTransforming protein RhoA/0.535
1xtsGTPGTP-binding protein Rheb/0.530
4nyiGNPGTPase HRas/0.529
5dhaGNPGTP-binding nuclear protein Ran/0.529
1xtrGNPGTP-binding protein Rheb/0.527
5hpyGDPTransforming protein RhoA/0.524
2rgeGNPGTPase HRas/0.520
2clsGTPRho-related GTP-binding protein Rho6/0.518
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.517
3e5hGNPRas-related protein Rab-28/0.517
1zc4GNPRas-related protein Ral-A/0.516
3th5GNPRas-related C3 botulinum toxin substrate 1/0.515
3a6pGTPGTP-binding nuclear protein Ran/0.512
3nbzGTPGTP-binding nuclear protein Ran/0.511
2gilGTPRas-related protein Rab-6A/0.509
3w3zGTPGTP-binding nuclear protein Ran/0.509
1g17GNPRas-related protein SEC4/0.508
3bbpGTPRas-related protein Rab-6A/0.507
4nyjGNPGTPase HRas/0.507
3ddcGNPGTPase HRas/0.506
3oivGNPGTPase HRas/0.506
2rgbGNPGTPase HRas/0.505
2zetGTPRas-related protein Rab-27B/0.505
1gwnGTPRho-related GTP-binding protein RhoE/0.504
2c5lGTPGTPase HRas/0.504
3kkoGNPRas-related protein M-Ras/0.504
2bkuGTPGTP-binding nuclear protein Ran/0.503
3lawGNPRas-related protein Rab-7a/0.503
2rgcGNPGTPase HRas/0.502
4k81GTPGTPase HRas/0.501
1t91GTPRas-related protein Rab-7a/0.500
1yhnGTPRas-related protein Rab-7a/0.500
3lbnGNPGTPase HRas/0.500
4hdqGNPRas-related protein Rap-1b/0.498
2fe4GDPRas-related protein Rab-6B/0.497
1yzqGNPRas-related protein Rab-6A/0.494
3kucGDPRas-related protein Rap-1A/0.493
1vg8GNPRas-related protein Rab-7a/0.492
4o25GTPGTP-binding protein Rheb/0.492
1zc3GNPRas-related protein Ral-A/0.491
3oiuGNPGTPase HRas/0.489
4dltGNPGTPase HRas/0.489
1lfdGNPGTPase HRas/0.487
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.486
3rabGNPRas-related protein Rab-3A/0.486
4dsnGCPGTPase KRas/0.486
3pitGNPRas-related protein M-Ras/0.485
3tgpGNPGTPase HRas/0.485
3tnfGNPRas-related protein Rab-8A/0.484
4hdoGNPRas-related protein Rap-1b/0.483
4ol0GTPGTP-binding nuclear protein Ran/0.482
4xvrGNPGTPase HRas/0.482
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.479
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.479
1z2cGNPRho-related GTP-binding protein RhoC/0.476
3v4fGNPGTPase HRas/0.476
4kvgGTPRas-related protein Rap-1A/0.473
4lhwGNPRas-related protein Rab-8A/0.471
4qxaGTPRas-related protein Rab-9A/0.468
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.467
1ibrGNPGTP-binding nuclear protein Ran/0.466
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.465
3oiwGNPGTPase HRas/0.464
4rkfGNPRas-related protein Rab-3/0.464
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.463
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.462
2ffqGSPRas-related protein Rab-6B/0.461
3cphGDPRas-related protein SEC4/0.461
4cymGCPRas-related protein Rab-32/0.461
4dvgGSPRho family GTPase/0.461
3rs7GNPGTPase HRas/0.459
4g0nGNPGTPase HRas/0.459
5jljGNPGTP-binding nuclear protein Ran/0.459
3lbhGNPGTPase HRas/0.457
4dlzGNPGTPase HRas/0.456
3i3sGNPGTPase HRas/0.454
3l8yGNPGTPase HRas/0.454
3tklGTPRas-related protein Rab-1A/0.454
4dlwGNPGTPase HRas/0.454
2msdGNPMHC class I alpha chain/0.453
3ea5GDPGTP-binding nuclear protein Ran/0.453
5b2zGNPGTPase HRas/0.451
3rs5GNPGTPase HRas/0.450
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.449
3tsoGNPRas-related protein Rab-25/0.449
3k8yGNPGTPase HRas/0.448
4xvqGNPGTPase HRas/0.448
3qbtGNPRas-related protein Rab-8A/0.446
3lbiGNPGTPase HRas/0.445
1uadGNPRas-related protein Ral-A/0.444
2rggGNPGTPase HRas/0.444
2cl6CAGGTPase HRas/0.443
3x1zGNPRas-related protein Rap-1b/0.441