sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 1.000 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.513 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.504 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.504 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.500 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.498 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.498 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.494 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.493 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.493 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.492 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.491 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.490 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.490 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.489 | |
| 2j62 | GSZ | O-GlcNAcase NagJ | / | 0.488 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.488 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.488 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.485 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.485 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.485 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.484 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.484 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.482 | |
| 3ele | PLP | Aminotransferase | / | 0.482 | |
| 4xba | GMP | Aprataxin-like protein | 3 | 0.482 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.481 | |
| 2j5s | KTA | Alr4455 protein | / | 0.481 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 3e6e | DCS | Alanine racemase | / | 0.481 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.481 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.479 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.479 | |
| 2bt4 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.478 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.477 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.477 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.476 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.476 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.476 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.476 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.476 | |
| 1e2n | RCA | Thymidine kinase | / | 0.475 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
| 3b9l | AZZ | Serum albumin | / | 0.475 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.474 | |
| 4xba | 5GP | Aprataxin-like protein | 3 | 0.474 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.473 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.472 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.472 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.472 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.472 | |
| 1eyy | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.471 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.471 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 4b6r | 3DQ | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.471 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 1lke | DOG | Bilin-binding protein | / | 0.470 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.470 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.470 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.470 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.470 | |
| 1n1e | NDE | Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal | 1.1.1.8 | 0.469 | |
| 1zdw | FLV | Prenyltransferase | / | 0.469 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.469 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.468 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.468 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.468 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.468 | |
| 4b6s | 2HN | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.468 | |
| 1c7o | PPG | Hemolysin | / | 0.467 | |
| 2a4x | BLM | Mitomycin-binding protein | / | 0.467 | |
| 2rd6 | 78P | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.467 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.467 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.466 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.466 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.466 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.466 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 3cow | 52H | Pantothenate synthetase | 6.3.2.1 | 0.466 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.466 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.466 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.465 | |
| 2v95 | HCY | Corticosteroid-binding globulin | / | 0.465 | |
| 4y38 | 0A9 | Endothiapepsin | 3.4.23.22 | 0.465 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.464 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.464 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.464 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.464 | |
| 4x7v | MIV | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.464 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.463 | |
| 1kia | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.463 | |
| 1rxj | BNI | Streptavidin | / | 0.463 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.462 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.462 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.462 | |
| 4img | NGF | N-acetylneuraminate lyase | / | 0.462 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.461 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.461 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.461 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2v5u | FMN | Flavodoxin | / | 0.461 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.461 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.461 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.460 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.460 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.460 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.460 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.460 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.460 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1vft | DCS | Alanine racemase | / | 0.459 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.459 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.459 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.459 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.459 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.459 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.459 | |
| 5d4v | YGP | Uncharacterized protein MJ0489 | / | 0.459 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3g0g | RUM | Dipeptidyl peptidase 4 | / | 0.458 | |
| 3wid | NAP | Glucose 1-dehydrogenase | / | 0.458 | |
| 4af6 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.458 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.458 | |
| 1fkj | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.457 | |
| 1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.457 | |
| 1xuz | MMN | Capsule biosynthesis protein | / | 0.457 | |
| 2dxi | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.457 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.457 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.456 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.456 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.456 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.456 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.456 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.456 | |
| 2vd7 | PD2 | Lysine-specific demethylase 4A | 1.14.11 | 0.456 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.456 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2g1a | 5HG | Class B acid phosphatase | 3.1.3.2 | 0.455 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.455 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 3t64 | DU3 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.455 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.455 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.455 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.454 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.454 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.454 | |
| 3tfn | 2CJ | Dehydrosqualene synthase | / | 0.454 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.454 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.454 | |
| 1ja0 | FAD | NADPH--cytochrome P450 reductase | / | 0.453 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.453 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2r3x | GTX | Glutathione S-transferase A1 | 2.5.1.18 | 0.453 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.453 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2xvh | NAP | Putative flavin-containing monooxygenase | / | 0.453 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.453 | |
| 3d4s | TIM | Beta-2 adrenergic receptor | / | 0.453 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.452 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.451 | |
| 1q6i | FK5 | FKBP-type peptidyl-prolyl cis-trans isomerase FkpA | 5.2.1.8 | 0.451 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2acw | UPG | Glycosyltransferase | / | 0.451 | |
| 2nm2 | NEU | Dihydroneopterin aldolase | / | 0.451 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.451 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.451 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.451 | |
| 3eku | CY9 | Actin-5C | / | 0.451 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.451 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.451 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.451 | |
| 4iil | RBF | Membrane lipoprotein TpN38(b) | / | 0.451 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.451 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.451 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.451 | |
| 4wrk | DUP | DUTPase | / | 0.451 | |
| 4y17 | LAE | Transcriptional regulator of ftsQAZ gene cluster | / | 0.451 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.450 | |
| 1kru | IPT | Galactoside O-acetyltransferase | 2.3.1.18 | 0.450 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 2g6p | HM2 | Methionine aminopeptidase 1 | / | 0.450 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.450 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 2q0l | NAP | Thioredoxin reductase | 1.8.1.9 | 0.450 | |
| 4d6q | PD2 | Lysine-specific demethylase 4D | 1.14.11 | 0.450 | |
| 4j7g | TRH | PCZA361.3 | / | 0.450 | |
| 4j7h | TRH | PCZA361.3 | / | 0.450 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.450 | |
| 1ppl | 1Z7 | Penicillopepsin-1 | 3.4.23.20 | 0.449 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.449 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.449 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.449 | |
| 2fxf | ACO | Diamine acetyltransferase 1 | / | 0.449 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.449 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3dzl | 3OC | Phenazine biosynthesis protein A/B | / | 0.449 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.449 | |
| 3pi0 | F91 | Endothiapepsin | 3.4.23.22 | 0.449 | |
| 4e2x | TYD | Methyltransferase | / | 0.449 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4iku | SHX | Methionine aminopeptidase 1 | / | 0.449 | |
| 5c8a | 5AD | Probable transcriptional regulator | / | 0.449 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.448 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.448 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.448 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.448 | |
| 3ccc | 7AC | Dipeptidyl peptidase 4 | / | 0.448 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.448 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.448 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.448 | |
| 3o76 | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.448 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.448 | |
| 3uaw | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.448 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.448 | |
| 4mka | 2AY | Genome polyprotein | 2.7.7.48 | 0.448 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.448 | |
| 5fsi | 8DG | 7,8-dihydro-8-oxoguanine triphosphatase | 3.6.1.55 | 0.448 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1pfy | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.447 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.447 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.447 | |
| 2qzr | S79 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 3biy | 01K | Histone acetyltransferase p300 | / | 0.447 | |
| 3clt | FAD | Electron transfer flavoprotein subunit alpha | / | 0.447 | |
| 3n3a | FMN | Protein NrdI | / | 0.447 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.447 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.447 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4e7r | 0NW | Prothrombin | 3.4.21.5 | 0.447 | |
| 4iae | 1DX | Alr2278 protein | / | 0.447 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1ja0 | FMN | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.446 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.446 | |
| 2wca | NP6 | O-GlcNAcase BT_4395 | / | 0.446 | |
| 3iob | A4D | Pantothenate synthetase | 6.3.2.1 | 0.446 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.446 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.446 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4ikt | TFV | Methionine aminopeptidase 1 | / | 0.446 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.446 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.445 | |
| 1w7g | MIU | Prothrombin | 3.4.21.5 | 0.445 | |
| 2ejz | SAH | Diphthine synthase | / | 0.445 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.445 | |
| 2xpc | 051 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.445 | |
| 3bt9 | DEQ | HTH-type transcriptional regulator QacR | / | 0.445 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.445 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.445 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4k36 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.445 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.445 | |
| 4rel | KMP | Glycosyltransferase | / | 0.445 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.444 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.444 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.444 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.444 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.444 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.444 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.444 | |
| 2wec | PP5 | Penicillopepsin-1 | 3.4.23.20 | 0.444 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 3arv | SAU | Chitinase A | / | 0.444 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.444 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.444 | |
| 4djv | 0KM | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.444 | |
| 4qfz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 4wcx | SAM | Biotin and thiamin synthesis associated | / | 0.444 | |
| 5c8d | 5AD | Probable transcriptional regulator | / | 0.444 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.444 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1pk9 | 2FA | Purine nucleoside phosphorylase DeoD-type | / | 0.443 | |
| 1wl4 | COA | Acetyl-CoA acetyltransferase, cytosolic | 2.3.1.9 | 0.443 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.443 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.443 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.443 | |
| 3q8u | ADP | Nucleoside diphosphate kinase | / | 0.443 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.443 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.443 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.443 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.442 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.442 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 1sq5 | ADP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.442 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.442 | |
| 2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 2cje | DUN | DUTPase | / | 0.442 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.442 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2hq9 | FAD | Mll6688 protein | / | 0.442 | |
| 2hzq | STR | Apolipoprotein D | / | 0.442 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.442 | |
| 3cvk | N34 | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 3ie3 | N11 | Glutathione S-transferase P | 2.5.1.18 | 0.442 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.442 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1nbh | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.441 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.441 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 2bp1 | NDP | Aflatoxin B1 aldehyde reductase member 2 | / | 0.441 | |
| 2dg9 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.441 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.441 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.441 | |
| 3iu8 | T03 | Methionine aminopeptidase 2 | / | 0.441 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 3zpq | XF5 | Beta-1 adrenergic receptor | / | 0.441 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4jpc | 1M6 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4mk8 | 28Q | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 4mm9 | FVX | Na(+):neurotransmitter symporter (Snf family) | / | 0.441 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 1n2v | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 1xvv | CCQ | L-carnitine CoA-transferase | / | 0.440 | |
| 2cbj | OAN | O-GlcNAcase NagJ | / | 0.440 | |
| 2jgb | MGT | Eukaryotic translation initiation factor 4E type 2 | / | 0.440 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.440 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2xb9 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.440 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.440 | |
| 3t0i | SAH | Putative methyltransferase | / | 0.440 | |
| 3t70 | DU4 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.440 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4gh1 | 0WX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 4hr2 | ADP | Nucleoside diphosphate kinase | / | 0.440 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.440 |