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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
8dfr NDP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
8dfr NDPDihydrofolate reductase 1.5.1.3 1.342
1dr5 NAPDihydrofolate reductase 1.5.1.3 1.176
2w3b NDPDihydrofolate reductase 1.5.1.3 1.173
1dr2 TAPDihydrofolate reductase 1.5.1.3 1.140
3nxx NDPDihydrofolate reductase 1.5.1.3 1.118
1dr3 TAPDihydrofolate reductase 1.5.1.3 1.102
3d84 NDPDihydrofolate reductase 1.5.1.3 0.959
4m6j NDPDihydrofolate reductase 1.5.1.3 0.947
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.921
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.861
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.860
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.857
3tqa NDPDihydrofolate reductase / 0.850
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.832
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.813
1m78 NDPDihydrofolate reductase 1.5.1.3 0.794
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.781
2cig 1DGDihydrofolate reductase 1.5.1.3 0.777
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.759
1drh NAPDihydrofolate reductase 1.5.1.3 0.755
4xt5 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.750
5ecc NAPDehydrofolate reductase type I / 0.749
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.738
2xw7 NDPDihydrofolate reductase / 0.732
3qlr NDPDihydrofolate reductase 1.5.1.3 0.732
1ai9 NDPDihydrofolate reductase 1.5.1.3 0.729
1juv NDPDihydrofolate reductase 1.5.1.3 0.718
3hbb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.714
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.710
5a03 NDPGlucose-fructose oxidoreductase / 0.698
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.694
5a06 NDPGlucose-fructose oxidoreductase / 0.691
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.678
3qls NDPDihydrofolate reductase 1.5.1.3 0.669
2h2q NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.660
1rx8 NAPDihydrofolate reductase 1.5.1.3 0.656