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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
7dfr FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
7dfr FOLDihydrofolate reductase 1.5.1.3 1.001
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.906
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.902
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.884
4x5f FOLDihydrofolate reductase 1.5.1.3 0.870
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.867
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.859
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.848
4kjj FOLDihydrofolate reductase 1.5.1.3 0.845
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.844
1dyi FOLDihydrofolate reductase 1.5.1.3 0.836
4fhb FOLDihydrofolate reductase 1.5.1.3 0.836
1dyh DZFDihydrofolate reductase 1.5.1.3 0.832
4m6k FOLDihydrofolate reductase 1.5.1.3 0.832
4x5g FOLDihydrofolate reductase 1.5.1.3 0.831
1dyj DDFDihydrofolate reductase 1.5.1.3 0.830
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.823
4i1n FOLDihydrofolate reductase 1.5.1.3 0.823
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.817
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.816
1dre MTXDihydrofolate reductase 1.5.1.3 0.814
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.803
4i13 FOLDihydrofolate reductase 1.5.1.3 0.802
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.800
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.797
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.795
2w3m FOLDihydrofolate reductase 1.5.1.3 0.784
3tq9 MTXDihydrofolate reductase / 0.783
1re7 FOLDihydrofolate reductase 1.5.1.3 0.777
5ccc DDFDihydrofolate reductase 1.5.1.3 0.772
2zza FOLDihydrofolate reductase / 0.771
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.770
4keb FOLDihydrofolate reductase 1.5.1.3 0.770
4kfj FOLDihydrofolate reductase 1.5.1.3 0.769
3tqb FOLDihydrofolate reductase / 0.766
3dau MTXDihydrofolate reductase 1.5.1.3 0.758
1hfr MOTDihydrofolate reductase 1.5.1.3 0.757
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.757
1tdr MTXDihydrofolate reductase 1.5.1.3 0.756
1u72 MTXDihydrofolate reductase 1.5.1.3 0.753
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.752
1hfq MOTDihydrofolate reductase 1.5.1.3 0.746
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.745
2d0k FOLDihydrofolate reductase 1.5.1.3 0.744
1jom FFODihydrofolate reductase 1.5.1.3 0.737
1e26 GPBDihydrofolate reductase 1.5.1.3 0.736
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.733
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.733
1dhj MTXDihydrofolate reductase 1.5.1.3 0.731
1dhi MTXDihydrofolate reductase 1.5.1.3 0.729
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.729
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.728
1df7 MTXDihydrofolate reductase 1.5.1.3 0.726
1dhf FOLDihydrofolate reductase 1.5.1.3 0.726
4p68 MTXDihydrofolate reductase / 0.726
3frd DHFDihydrofolate reductase 1.5.1.3 0.723
1hfp MOTDihydrofolate reductase 1.5.1.3 0.720
3dfr MTXDihydrofolate reductase 1.5.1.3 0.720
1dra MTXDihydrofolate reductase 1.5.1.3 0.719
1drb MTXDihydrofolate reductase 1.5.1.3 0.718
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.718
4qi9 MTXDihydrofolate reductase / 0.716
4p66 MTXDihydrofolate reductase / 0.714
3drc MTXDihydrofolate reductase 1.5.1.3 0.712
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.711
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.711
1dls MTXDihydrofolate reductase 1.5.1.3 0.709
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.709
4x5h FOLDihydrofolate reductase 1.5.1.3 0.709
3och 2MXDihydrofolate reductase 1.5.1.3 0.708
3ghw GHWDihydrofolate reductase 1.5.1.3 0.707
4m6l 21VDihydrofolate reductase 1.5.1.3 0.704
1ohj COPDihydrofolate reductase 1.5.1.3 0.702
4dfr MTXDihydrofolate reductase 1.5.1.3 0.698
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.695
2drc MTXDihydrofolate reductase 1.5.1.3 0.692
1drf FOLDihydrofolate reductase 1.5.1.3 0.691
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.689
1u70 MTXDihydrofolate reductase 1.5.1.3 0.688
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.682
1dds MTXDihydrofolate reductase 1.5.1.3 0.677
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.676
4x5i FOLDihydrofolate reductase 1.5.1.3 0.676
5hi6 MTXDihydrofolate reductase / 0.673
1bp6 UMPThymidylate synthase / 0.672
1daj MOTDihydrofolate reductase 1.5.1.3 0.665
3ia4 MTXDihydrofolate reductase / 0.663
1drt PCVClavaminate synthase 1 1.14.11.21 0.660
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.660
3ghv GHCDihydrofolate reductase 1.5.1.3 0.660
1hbn TP7Methyl-coenzyme M reductase I subunit alpha 2.8.4.1 0.659
1hbn TP7Methyl-coenzyme M reductase I subunit beta 2.8.4.1 0.659
3eig MTXDihydrofolate reductase 1.5.1.3 0.659
2qk8 MTXDihydrofolate reductase / 0.657
1ddr MTXDihydrofolate reductase 1.5.1.3 0.651
1jmf UMPThymidylate synthase / 0.651
2ay2 CXPAromatic-amino-acid aminotransferase 2.6.1.57 0.650