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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5l8k ADP Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5l8k ADPAurora kinase A 2.7.11.1 0.896
5l8j ADPAurora kinase A 2.7.11.1 0.828
5l8l ADPAurora kinase A 2.7.11.1 0.753
2wqe ADPAurora kinase A 2.7.11.1 0.751
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.733
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.729
2pui ADPMethylthioribose kinase 2.7.1.100 0.704
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.702
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.700
3c4w ATPRhodopsin kinase / 0.697
4dee ADPAurora kinase A 2.7.11.1 0.694
4b8l A0PAurora kinase B-A 2.7.11.1 0.693
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.693
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.691
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.688
4c3r ACPAurora kinase A 2.7.11.1 0.687
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.686
3b2t M33Fibroblast growth factor receptor 2 / 0.685
4o1p ANPRibonuclease L / 0.683
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.682
4n57 ADPAPH(2'')-Id / 0.681
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.680
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.679
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.679
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.678
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.678
5dnr ATPAurora kinase A 2.7.11.1 0.678
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.676
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.676
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.675
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.674
2pup ADPMethylthioribose kinase 2.7.1.100 0.673
2pzp ACPFibroblast growth factor receptor 2 / 0.671
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.671
2pz5 ACPFibroblast growth factor receptor 2 / 0.670
2pmi AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.668
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.667
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.667
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.665
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.664
3ori AGSSerine/threonine protein kinase / 0.664
3c4z ADPRhodopsin kinase / 0.663
2pyw ADPMethylthioribose kinase 2.7.1.100 0.662
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.661
2olc ADPMethylthioribose kinase 2.7.1.100 0.660
3c50 ADPRhodopsin kinase / 0.660
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.660
3orm AGSSerine/threonine protein kinase / 0.659
4j98 ACPFibroblast growth factor receptor 2 / 0.659
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.659
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.659
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.658
4j97 ACPFibroblast growth factor receptor 2 / 0.657
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.656
4o4f ATPKinase / 0.656
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.656
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.655
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.655
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.654
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.654
3bu5 ATPInsulin receptor 2.7.10.1 0.654
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.651
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.651
3t8o ATPRhodopsin kinase / 0.651
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.651
4q5h ANPProtein kinase OspG 2.7 0.651