sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5jyd | NAD | Short chain dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 5jyd | NAD | Short chain dehydrogenase | / | 1.272 | |
| 3r3s | NAD | Putative oxidoreductase | / | 1.120 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 1.028 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.891 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.887 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.877 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.856 | |
| 4clo | NAP | Pteridine reductase | / | 0.851 | |
| 4kwh | NAP | Reductase homolog | / | 0.843 | |
| 1w8d | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.834 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.824 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.821 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.819 | |
| 3bmo | NAP | Pteridine reductase | / | 0.817 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.810 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.810 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.803 | |
| 1w73 | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.803 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.803 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.803 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.800 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.798 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.797 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.796 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.789 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.785 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.785 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.780 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.780 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.779 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.778 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.778 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.777 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.775 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.774 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.774 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.773 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.773 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.768 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.768 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.766 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.766 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.764 | |
| 2bfo | NDP | Pteridine reductase 1 | 1.5.1.33 | 0.762 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.762 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.762 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.761 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.761 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.760 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.760 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.759 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.759 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.758 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.758 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.758 | |
| 4u7w | NDP | MxaA | / | 0.757 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.756 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.755 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.754 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.754 | |
| 1sny | NAP | LD36273p | / | 0.753 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.752 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.751 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.751 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.751 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.750 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.750 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.749 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.748 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.747 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.745 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.745 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.743 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.743 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.743 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.740 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.739 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.739 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.738 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.737 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.737 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.736 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.735 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.734 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.732 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.731 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.730 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.729 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.729 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.729 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.727 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.726 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.726 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.724 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.724 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.723 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.723 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.723 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.722 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.722 | |
| 3icp | NAD | NAD-dependent epimerase/dehydratase | / | 0.721 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.720 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.719 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.719 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.719 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.718 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.718 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.718 | |
| 4hxy | NDP | Plm1 | / | 0.718 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.717 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.717 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.717 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.716 | |
| 3sju | NDP | Keto reductase | / | 0.716 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.715 | |
| 3uce | NDP | Dehydrogenase | / | 0.715 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.714 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.714 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.714 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.714 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.713 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.712 | |
| 4bii | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.712 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.711 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.711 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.711 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.710 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.710 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.710 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.710 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.710 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.710 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.709 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.709 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.708 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.708 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.708 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.707 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.707 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.707 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.707 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.707 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.707 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.705 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.704 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.704 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.704 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.703 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.703 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.703 | |
| 2yw9 | NAP | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.702 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.702 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.701 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.700 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.699 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.699 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.699 | |
| 4id9 | NAD | Putative UDP-glucose 4-epimerase | / | 0.699 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.699 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.698 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.697 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.696 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.696 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.696 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.695 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.695 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.694 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.693 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.693 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.692 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.692 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.691 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.691 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.691 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.690 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.690 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.690 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.689 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.688 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.687 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.687 | |
| 1fk8 | NAD | 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase | 1.1.1.50 | 0.686 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.686 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.686 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.684 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.683 | |
| 1n7g | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.683 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.683 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.683 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.682 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.681 | |
| 3sxp | NAD | ADP-L-glycero-D-mannoheptose-6-epimerase | / | 0.681 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.681 | |
| 1rpn | NDP | GDP-mannose 4,6-dehydratase | / | 0.680 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.680 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.680 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.678 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.678 | |
| 4lk3 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.678 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.677 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.676 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.676 | |
| 4bgi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.675 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.673 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.672 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.671 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.671 | |
| 4qed | NAP | ElxO | / | 0.671 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.670 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.670 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.670 | |
| 1iy8 | NAD | Levodione reductase | / | 0.669 | |
| 3mje | NDP | AmphB | / | 0.669 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.669 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.669 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.668 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.667 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.667 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.667 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.667 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.666 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.666 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.665 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.665 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.664 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.663 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.663 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.662 | |
| 5d2e | NAP | MlnE | / | 0.661 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.660 | |
| 1b14 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.659 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.659 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.658 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.656 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.655 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.655 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.654 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.654 | |
| 4qec | NAP | ElxO | / | 0.654 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.653 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.653 | |
| 1m76 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.652 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.652 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.652 | |
| 2jcs | TTP | Deoxynucleoside kinase | / | 0.651 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.650 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.650 |