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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5iqe GNP Bifunctional AAC/APH 2.3.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5iqe GNPBifunctional AAC/APH 2.3.1 1.087
5iqa GNPBifunctional AAC/APH 2.3.1 1.034
5iqd GNPBifunctional AAC/APH 2.3.1 0.993
5iqi GNPBifunctional AAC/APH 2.3.1 0.981
5iqb GNPBifunctional AAC/APH 2.3.1 0.906
5iqh GNPBifunctional AAC/APH 2.3.1 0.879
5byl GCPBifunctional AAC/APH 2.3.1 0.868
3tdw GDPGentamicin resistance protein / 0.820
4ork GDPBifunctional AAC/APH 2.3.1 0.792
3tdv GDPGentamicin resistance protein / 0.786
5iqg GDPBifunctional AAC/APH 2.3.1 0.785
5iqf GDPBifunctional AAC/APH 2.3.1 0.743
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.732
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.731
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.720
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.717
4dee ADPAurora kinase A 2.7.11.1 0.715
4xlv ACPInsulin receptor 2.7.10.1 0.715
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.714
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.711
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.708
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.708
4gyi ADPUncharacterized protein / 0.707
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.706
2pui ADPMethylthioribose kinase 2.7.1.100 0.705
3bu5 ATPInsulin receptor 2.7.10.1 0.705
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.704
1mq4 ADPAurora kinase A 2.7.11.1 0.703
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.703
4ceg ADPAurora kinase A 2.7.11.1 0.703
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.698
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
4o4e ATPKinase / 0.695
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.694
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.694
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.694
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.692
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.689
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
2pyw ADPMethylthioribose kinase 2.7.1.100 0.687
3c50 ADPRhodopsin kinase / 0.687
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.686
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.686
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.686
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.685
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
4o4f ATPKinase / 0.684
4utd ACPAurora kinase A 2.7.11.1 0.681
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.680
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.680
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.680
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.680
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
5dn3 ATPAurora kinase A 2.7.11.1 0.680
5drd ATPAurora kinase A 2.7.11.1 0.680
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.678
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.678
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.675
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.674
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.673
4ffm ADPUncharacterized protein / 0.673
5dr2 ATPAurora kinase A 2.7.11.1 0.673
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
5dos ATPAurora kinase A 2.7.11.1 0.672
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.670
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.670
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.669
5dt3 ATPAurora kinase A 2.7.11.1 0.668
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.667
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.666
1m0w ANPGlutathione synthetase 6.3.2.3 0.665
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.664
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.664
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.664
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.663
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.662
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.661
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.661
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.661
4ffl ADPUncharacterized protein / 0.661
4n57 ADPAPH(2'')-Id / 0.660
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.659
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.657
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.657
3wo1 ADPAlanine--anticapsin ligase / 0.656
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.656
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.656
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.655
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.654
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.653
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.653
2pup ADPMethylthioribose kinase 2.7.1.100 0.652
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.652
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.651
4qny ANPMitogen activated protein kinase, putative / 0.651
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.651