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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5iqa GNP Bifunctional AAC/APH 2.3.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5iqa GNPBifunctional AAC/APH 2.3.1 1.052
5iqe GNPBifunctional AAC/APH 2.3.1 1.034
5iqd GNPBifunctional AAC/APH 2.3.1 1.012
5iqi GNPBifunctional AAC/APH 2.3.1 0.968
5iqh GNPBifunctional AAC/APH 2.3.1 0.888
5iqb GNPBifunctional AAC/APH 2.3.1 0.885
5byl GCPBifunctional AAC/APH 2.3.1 0.881
5iqf GDPBifunctional AAC/APH 2.3.1 0.825
3tdw GDPGentamicin resistance protein / 0.816
4ork GDPBifunctional AAC/APH 2.3.1 0.801
5iqg GDPBifunctional AAC/APH 2.3.1 0.788
3tdv GDPGentamicin resistance protein / 0.743
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.728
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.716
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.714
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.712
4xlv ACPInsulin receptor 2.7.10.1 0.712
1mq4 ADPAurora kinase A 2.7.11.1 0.707
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.707
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.707
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.707
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.706
2pyw ADPMethylthioribose kinase 2.7.1.100 0.705
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
2pui ADPMethylthioribose kinase 2.7.1.100 0.704
4ceg ADPAurora kinase A 2.7.11.1 0.703
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.702
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.702
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.701
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.700
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.700
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.697
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.696
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.694
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.693
4dee ADPAurora kinase A 2.7.11.1 0.692
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.690
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.688
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.687
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.686
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.685
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.685
4gyi ADPUncharacterized protein / 0.685
4utd ACPAurora kinase A 2.7.11.1 0.685
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.683
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.681
3bu5 ATPInsulin receptor 2.7.10.1 0.681
4o4f ATPKinase / 0.681
5dn3 ATPAurora kinase A 2.7.11.1 0.681
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.680
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.679
4n57 ADPAPH(2'')-Id / 0.678
5eg3 ACPFibroblast growth factor receptor 2 / 0.678
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.677
5dt3 ATPAurora kinase A 2.7.11.1 0.677
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.676
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.675
3c50 ADPRhodopsin kinase / 0.675
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.674
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.674
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.673
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.672
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.672
4o4e ATPKinase / 0.671
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4ffm ADPUncharacterized protein / 0.669
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
3dyn PCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A / 0.667
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.667
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.667
3cly ACPFibroblast growth factor receptor 2 / 0.666
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.665
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.665
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.665
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.665
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.664
5dos ATPAurora kinase A 2.7.11.1 0.664
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.663
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.662
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.661
5dr2 ATPAurora kinase A 2.7.11.1 0.661
2pup ADPMethylthioribose kinase 2.7.1.100 0.660
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.660
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.659
4ffl ADPUncharacterized protein / 0.659
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.659
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.659
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.658
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.657
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.657
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.657
4ffr ATPUncharacterized protein / 0.657
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.657
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.656
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.653
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.653
5dt4 ATPAurora kinase A 2.7.11.1 0.653
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.652
2pun ACPMethylthioribose kinase 2.7.1.100 0.652
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.651
2j9g ADPBiotin carboxylase 6.3.4.14 0.651
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.651
4o4d ATPKinase / 0.651
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.650
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.650
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.650