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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5iot UMP Flavin-dependent thymidylate synthase 2.1.1.148

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5iot UMPFlavin-dependent thymidylate synthase 2.1.1.148 0.948
1lny IMOAdenylosuccinate synthetase isozyme 1 / 0.683
2wky IBCGlutamate receptor ionotropic, kainate 1 / 0.670
2gpj FADSiderophore-interacting protein / 0.666
1toi HCIAspartate aminotransferase 2.6.1.1 0.662
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.658
5li5 THR_ALA_ASN_PRO_SEPKLTH0G14146p / 0.657
1toj HCIAspartate aminotransferase 2.6.1.1 0.655
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.654
1p9b IMOAdenylosuccinate synthetase / 0.652
1cg3 IMOAdenylosuccinate synthetase / 0.651
4x5h FOLDihydrofolate reductase 1.5.1.3 0.651
2rds 1PL1-deoxypentalenic acid 11-beta-hydroxylase 1.14.11.35 0.650
4x5i FOLDihydrofolate reductase 1.5.1.3 0.650