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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5hyr EST Estrogen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5hyr ESTEstrogen receptor / 1.201
3uud ESTEstrogen receptor / 1.100
5dxg ESTEstrogen receptor / 1.090
1gwr ESTEstrogen receptor / 1.084
4pxm ESTEstrogen receptor / 1.068
2yja ESTEstrogen receptor / 1.067
3l03 4OHEstrogen receptor / 1.059
2qgt EEDEstrogen receptor / 1.058
3q95 ESLEstrogen receptor / 1.012
5dx3 ESTEstrogen receptor / 0.982
2g5o DRQEstrogen receptor / 0.973
2j7x ESTEstrogen receptor beta / 0.961
2b1z 17MEstrogen receptor / 0.955
3oll ESTEstrogen receptor beta / 0.935
4j24 ESTEstrogen receptor beta / 0.926
2ocf ESTEstrogen receptor / 0.920
1g50 ESTEstrogen receptor / 0.883
2yat EEUEstrogen receptor / 0.882
2p15 EZTEstrogen receptor / 0.811
1x7e 244Estrogen receptor / 0.768
2qa8 GENEstrogen receptor / 0.744
1i5r HYCEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.732
4j26 ESTEstrogen receptor beta / 0.728
1sqn NDRProgesterone receptor / 0.725
2w8y 486Progesterone receptor / 0.725
1x7r GENEstrogen receptor / 0.723
1lhu ESTSex hormone-binding globulin / 0.716
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.712
1kdm DHTSex hormone-binding globulin / 0.706
4ofu DHTAndrogen receptor / 0.705
2pog WSTEstrogen receptor / 0.701
2pnu ENMAndrogen receptor / 0.700
2aa5 STRMineralocorticoid receptor / 0.699
3eqm ASDAromatase 1.14.14.14 0.698
3up3 XCAaceDAF-12 / 0.697
1lho AOMSex hormone-binding globulin / 0.689
3ols ESTEstrogen receptor beta / 0.687
5l7d CLRSmoothened homolog / 0.687
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.683
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.682
4pp6 STLEstrogen receptor / 0.676
1zq5 E04Aldo-keto reductase family 1 member C3 / 0.675
2jn3 JN3Fatty acid-binding protein, liver / 0.675
4jvl ESTEstrogen sulfotransferase 2.8.2.4 0.675
4ofr DHTAndrogen receptor / 0.675
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.674
2rlc CHDCholoylglycine hydrolase 3.5.1.24 0.672
3ert OHTEstrogen receptor / 0.672
4a2j AS0Progesterone receptor / 0.672
1xq3 R18Androgen receptor / 0.670
3s79 ASDAromatase 1.14.14.14 0.669
1p8d CO1Oxysterols receptor LXR-beta / 0.667
3up0 D7SaceDAF-12 / 0.666
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.664
3bej MUFBile acid receptor / 0.661
3w5p 4OAVitamin D3 receptor / 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4e5f 0N7Polymerase acidic protein / 0.659
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.658
3w5q 3KLVitamin D3 receptor / 0.658
1uom PTIEstrogen receptor / 0.657
1xow R18Androgen receptor / 0.657
1gwq ZTWEstrogen receptor / 0.654
1ya3 STRMineralocorticoid receptor / 0.653
1equ EQIEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.652
2qo5 CHDFatty acid-binding protein 10-A, liver basic / 0.652
5epo TUD7-alpha-hydroxysteroid deydrogenase / 0.652
4qbj NHMGlycylpeptide N-tetradecanoyltransferase 2.3.1.97 0.651
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.650
1t5z DHTAndrogen receptor / 0.650
2ylp TESAndrogen receptor / 0.650