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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5hxw FAD L-amino acid deaminase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
5hxw FADL-amino acid deaminase / 1.490
5i39 FADL-amino acid deaminase / 1.341
4ysh FADGlycine oxidase / 0.983
3gsi FADDimethylglycine oxidase 1.5.3.10 0.907
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.883
3vqr FADPutative oxidoreductase / 0.874
3dme FADPutative conserved exported protein / 0.865
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.865
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.860
2du8 FADD-amino-acid oxidase 1.4.3.3 0.855
1kif FADD-amino-acid oxidase 1.4.3.3 0.850
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.842
4yjd FADD-amino-acid oxidase 1.4.3.3 0.835
3axb FADPutative oxidoreductase / 0.814
1ng4 FADGlycine oxidase 1.4.3.19 0.813
1ryi FADGlycine oxidase 1.4.3.19 0.813
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.813
2rgo FADAlpha-Glycerophosphate Oxidase / 0.809
1ng3 FADGlycine oxidase 1.4.3.19 0.803
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.798
4eqw FADCoenzyme A disulfide reductase / 0.798
1yqz FADCoenzyme A disulfide reductase / 0.795
1c0l FADD-amino-acid oxidase 1.4.3.3 0.794
4rsl FADFructosyl peptide oxidase / 0.780
2rgh FADAlpha-Glycerophosphate Oxidase / 0.778
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.776
3cuk FADD-amino-acid oxidase 1.4.3.3 0.773
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.772
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.771
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.767
3znp FADD-amino-acid oxidase 1.4.3.3 0.764
3ka7 FADPutative oxidoreductase / 0.763
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.763
3ad9 FADSubunit beta of sarcosine oxidase / 0.761
1c0k FADD-amino-acid oxidase 1.4.3.3 0.758
4em3 FADCoenzyme A disulfide reductase / 0.758
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.755
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.754
4eqx FADCoenzyme A disulfide reductase / 0.753
3atq FDAConserved Archaeal protein / 0.752
4bjz FADProbable salicylate monooxygenase / 0.749
4wct FADFructosyl amine:oxygen oxidoreductase / 0.748
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.747
4k5r FADOxygenase / 0.746
4opd FDAConserved Archaeal protein / 0.744
3rp8 FADFAD-dependent urate hydroxylase / 0.740
4x9m FADUncharacterized protein MG039 homolog / 0.740
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.739
2y48 FADLysine-specific histone demethylase 1A 1 0.739
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.738
5l3d FADLysine-specific histone demethylase 1A 1 0.736
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.734
4x9n FADUncharacterized protein MG039 homolog / 0.734
4opc FDAConserved Archaeal protein / 0.731
3icr FADCoenzyme A disulfide reductase / 0.730
3qvr FADGlucose oxidase 1.1.3.4 0.730
4bk3 FADProbable salicylate monooxygenase / 0.729
5cku FADL-ornithine N(5)-monooxygenase / 0.729
5j60 FADThioredoxin reductase / 0.729
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.727
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.727
1f8r FADL-amino-acid oxidase 1.4.3.2 0.725
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.725
3if9 FADGlycine oxidase 1.4.3.19 0.725
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.724
4j36 FADKynurenine 3-monooxygenase / 0.724
1f8s FADL-amino-acid oxidase 1.4.3.2 0.723
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.723
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.720
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.720
4eqs FADCoenzyme A disulfide reductase / 0.720
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.719
1rsg FADPolyamine oxidase FMS1 / 0.719
2iid FADL-amino-acid oxidase 1.4.3.2 0.719
4opg FDAConserved Archaeal protein / 0.719
4mih FADPyranose 2-oxidase 1.1.3.10 0.718
1ve9 FADD-amino-acid oxidase 1.4.3.3 0.717
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.717
3cty FADProbable thioredoxin reductase / 0.716
2yg7 FADPutrescine oxidase / 0.714
1ojt FADDihydrolipoyl dehydrogenase / 0.713
3qj4 FADRenalase / 0.713
1reo FADL-amino-acid oxidase 1.4.3.2 0.711
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.711
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.711
1qo8 FADFumarate reductase flavoprotein subunit / 0.710
2e1m FADL-glutamate oxidase / 0.710
2e48 FADD-amino-acid oxidase 1.4.3.3 0.710
1knr FADL-aspartate oxidase 1.4.3.16 0.706
4nm9 FADBifunctional protein PutA / 0.706
1tdo FADL-amino-acid oxidase 1.4.3.2 0.705
3cn8 FADPolyamine oxidase FMS1 / 0.705
4xbf FADLysine-specific histone demethylase 1A 1 0.705
1gal FADGlucose oxidase 1.1.3.4 0.704
1xpq FADPolyamine oxidase FMS1 / 0.704
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.704
4c3x FAD3-ketosteroid dehydrogenase / 0.703
3lsm SFDPyranose 2-oxidase / 0.702
3nlc FADUncharacterized protein / 0.702
1zx9 FADMercuric reductase 1.16.1.1 0.701
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.700
2wow FADTrypanothione reductase / 0.700
2yg5 FADPutrescine oxidase / 0.700
4u8o FDAUDP-galactopyranose mutase / 0.700
3zdn FADMonoamine oxidase N 1.4.3.4 0.698
1tj0 FADBifunctional protein PutA 1.5.5.2 0.696
1zk7 FADMercuric reductase 1.16.1.1 0.696
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.695
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.695
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.695
4ap3 FADSteroid monooxygenase / 0.695
1tdk FADL-amino-acid oxidase 1.4.3.2 0.694
1tdn FADL-amino-acid oxidase 1.4.3.2 0.694
2xvf FADPutative flavin-containing monooxygenase / 0.694
3ad9 NADSubunit alpha of sarocosine oxidase / 0.694
4gut FADLysine-specific histone demethylase 1B 1 0.694
1cf3 FADGlucose oxidase 1.1.3.4 0.693
1gpe FADGlucose oxidase 1.1.3.4 0.693
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.693
1tj2 FADBifunctional protein PutA 1.5.5.2 0.693
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.693
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.693
3ics FADCoenzyme A disulfide reductase / 0.693
4opi FDAConserved Archaeal protein / 0.693
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.693
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.693
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.692
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.692
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.692
5c3j FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.692
2ign FADPyranose 2-oxidase / 0.691
3qvp FADGlucose oxidase 1.1.3.4 0.691
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.690
3bi5 FADPolyamine oxidase FMS1 / 0.690
3cnd FADPolyamine oxidase FMS1 / 0.690
3gfz FMNUncharacterized protein / 0.690
4guu FA9Lysine-specific histone demethylase 1B 1 0.690
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.689
2jb1 FADL-amino acid oxidase / 0.689
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.689
4c3y FAD3-ketosteroid dehydrogenase / 0.689
4yac NAIC alpha-dehydrogenase / 0.689
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.688
4at0 FADPossible succinate dehydrogenase / 0.688
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.687
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.687
2b9y FADPutative aminooxidase / 0.686
2dw4 FADLysine-specific histone demethylase 1A 1 0.686
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.686
3k30 ADPHistamine dehydrogenase / 0.686
3kkj FADRenalase / 0.686
4z26 FADPutative GMC-type oxidoreductase R135 1 0.686
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.685
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.685
1cc2 FADCholesterol oxidase 1.1.3.6 0.684
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.684
4tm0 FADKtzI / 0.684
4wx1 FDAUDP-galactopyranose mutase / 0.684
4ynt FDAGlucose oxidase, putative / 0.684
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.684
1geu FADGlutathione reductase 1.8.1.7 0.683
4kx6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.683
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.682
4mok FADPyranose 2-oxidase / 0.682
1f8w FADNADH peroxidase 1.11.1.1 0.681
2jk6 FADTrypanothione reductase / 0.681
2v6o FADThioredoxin glutathione reductase / 0.681
3kve FADL-amino-acid oxidase / 0.681
4a6n FADTetX family tetracycline inactivation enzyme / 0.681
4b69 FADL-ornithine N(5)-monooxygenase / 0.681
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.681
2q7v FADThioredoxin reductase / 0.680
1tdf FADThioredoxin reductase 1.8.1.9 0.679
3bi2 FADPolyamine oxidase FMS1 / 0.679
3cnt FADPolyamine oxidase FMS1 / 0.679
3uth FDAUDP-galactopyranose mutase / 0.679
2o06 MTASpermidine synthase 2.5.1.16 0.678
2yg6 FADPutrescine oxidase / 0.678
3bg7 FADPyranose 2-oxidase / 0.678
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.678
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.678
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.677
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.677
4fwf FADLysine-specific histone demethylase 1B 1 0.677
1knp FADL-aspartate oxidase 1.4.3.16 0.676
2zbw FADFerredoxin--NADP reductase / 0.676
3fcj FADNitroalkane oxidase 1.7.3.1 0.676
3lsh FADPyranose 2-oxidase / 0.676
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.675
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.675
3utf FDAUDP-galactopyranose mutase / 0.675
3s5w FADL-ornithine N(5)-monooxygenase / 0.674
3utg FDAUDP-galactopyranose mutase / 0.674
4em4 FADCoenzyme A disulfide reductase / 0.674
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.674
1get FADGlutathione reductase 1.8.1.7 0.673
2h94 FADLysine-specific histone demethylase 1A 1 0.673
2jae FADL-amino acid oxidase / 0.673
3gfx FMNUncharacterized protein / 0.673
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.672
2jb2 FADL-amino acid oxidase / 0.672
2b9x FADPutative aminooxidase / 0.671
2npx FADNADH peroxidase 1.11.1.1 0.671
3lov FADProtoporphyrinogen oxidase / 0.671
3wv8 ATPHmd co-occurring protein HcgE / 0.671
4aos FADSteroid monooxygenase / 0.671
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.671
4hh0 FMNAppA protein / 0.671
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.671
1b4v FADCholesterol oxidase 1.1.3.6 0.670
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.670
2x8g FADThioredoxin glutathione reductase / 0.670
4opt FDAConserved Archaeal protein / 0.670
4tm3 FADKtzI / 0.670
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.669
3gfy FMNUncharacterized protein / 0.669
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.669
4qi5 FADCellobiose dehydrogenase / 0.669
3cgc FADCoenzyme A disulfide reductase / 0.668
4eqr FADCoenzyme A disulfide reductase / 0.668
4yry FADGlutamate synthase, beta subunit / 0.668
2bac FADPutative aminooxidase / 0.667
2q0k FADThioredoxin reductase 1.8.1.9 0.667
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.667
3grv ADNProbable ribosomal RNA small subunit methyltransferase A / 0.667
1n1p FADCholesterol oxidase 1.1.3.6 0.666
1nhr FADNADH peroxidase 1.11.1.1 0.666
2bab FADPutative aminooxidase / 0.666
2eq8 FADDihydrolipoyl dehydrogenase / 0.666
3r9u FADThioredoxin reductase / 0.666
4jq9 FADDihydrolipoyl dehydrogenase / 0.666
1mxt FAECholesterol oxidase 1.1.3.6 0.665
1n4v FADCholesterol oxidase 1.1.3.6 0.665
1n4w FADCholesterol oxidase 1.1.3.6 0.665
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.665
3hvk 719Catechol O-methyltransferase 2.1.1.6 0.665
3q9t FAYUncharacterized protein / 0.665
4xxg FADCholesterol oxidase 1.1.3.6 0.665
1feb FADTrypanothione reductase 1.8.1.12 0.664
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.664
3rw9 DSHSpermidine synthase 2.5.1.16 0.664
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.664
4j34 FADKynurenine 3-monooxygenase / 0.664
4nev FADTrypanothione reductase / 0.664
4yus FMNFamily 3 adenylate cyclase / 0.664
1f3p FADFerredoxin reductase / 0.663
1h83 FADPolyamine oxidase 1.5.3.14 0.663
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.663
2ar8 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.663
2ibt NEAModification methylase TaqI 2.1.1.72 0.663
4gcm FADThioredoxin reductase 1.8.1.9 0.663
2rab FADGlutathione amide reductase / 0.662
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.661
4f07 FADStyrene monooxygenase component 2 / 0.661
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.661
1l3i SAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) / 0.660
1tde FADThioredoxin reductase 1.8.1.9 0.660
2wba FADTrypanothione reductase 1.8.1.12 0.660
3awi FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC 1.5 0.660
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.660
4la1 FADThioredoxin glutathione reductase / 0.660
5j4e FMNSensory box protein / 0.660
2hko FADLysine-specific histone demethylase 1A 1 0.659
2okc SAMProbable type I restriction enzyme BthVORF4518P M protein 2.1.1.72 0.659
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.659
4opu FDAConserved Archaeal protein / 0.659
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.658
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.658
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.658
3ue6 FMNAureochrome1 / 0.658
4ech FADPolyamine oxidase FMS1 / 0.658
4hia FMNLOV protein / 0.658
4j57 FADThioredoxin reductase 2 1.8.1.9 0.658
4z24 FADPutative GMC-type oxidoreductase R135 1 0.658
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.657
1yy5 FADPolyamine oxidase FMS1 / 0.657
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.657
2xdo FADTetX family tetracycline inactivation enzyme / 0.657
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
3p9u FADTetX family tetracycline inactivation enzyme / 0.657
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
1bzl FADTrypanothione reductase 1.8.1.12 0.656
3hjk FADVivid PAS protein VVD / 0.656
4gde FDAUDP-galactopyranose mutase / 0.656
1gxf FADTrypanothione reductase 1.8.1.12 0.655
1yrx FMNAppA protein / 0.655
3k4n FADPyranose 2-oxidase / 0.654
4uir FADOleate hydratase 4.2.1.53 0.654
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.653
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.653
2gr0 FADFerredoxin reductase / 0.653
2oal FADFlavin-dependent tryptophan halogenase RebH 1.14.19.9 0.653
2r9z FADGlutathione amide reductase / 0.653
4eep FMNPhototropin-2 2.7.11.1 0.653
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.652
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.652
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.652
3djl FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.652
3ict FADCoenzyme A disulfide reductase / 0.652
3sfd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.652
4dsg FADUncharacterized protein / 0.652
4nzh FADL-ornithine N(5)-monooxygenase / 0.652
4u2s FDACholesterol oxidase 1.1.3.6 0.652
4u8p FDAUDP-galactopyranose mutase / 0.652
2gj3 FADNitrogen fixation regulatory protein 2.7.13.3 0.651
2iyi FMNAppA, antirepressor of ppsR, sensor of blue light / 0.651
4hsu FADLysine-specific histone demethylase 1B 1 0.651
4u8m FDAUDP-galactopyranose mutase / 0.651
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.650
3ukl FADUDP-galactopyranose mutase / 0.650
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.650
4opl FDAConserved Archaeal protein / 0.650