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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5hwr COA Hydroxymethylglutaryl-CoA synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5hwr COAHydroxymethylglutaryl-CoA synthase / 1.193
5hwp COAHydroxymethylglutaryl-CoA synthase / 0.973
5hwo HMGHydroxymethylglutaryl-CoA synthase / 0.947
5hwq CAAHydroxymethylglutaryl-CoA synthase / 0.896
2p8u COAHydroxymethylglutaryl-CoA synthase, cytoplasmic 2.3.3.10 0.731
2wya HMGHydroxymethylglutaryl-CoA synthase, mitochondrial 2.3.3.10 0.709
1ysl COAHydroxymethylglutaryl-CoA synthase 2.3.3.10 0.702
3sqz COAPutative hydroxymethylglutaryl-CoA synthase / 0.681
3te4 ACODopamine N-acetyltransferase / 0.661
1txt CAAHMG-CoA synthase / 0.651