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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5hi2 BAX Serine/threonine-protein kinase B-raf 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 1.200
1uwh BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.927
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.844
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.818
3gcs BAXMitogen-activated protein kinase 14 / 0.780
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.777
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.764
3ugc 046Tyrosine-protein kinase JAK2 / 0.761
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.731
3gcv SS6Mitogen-activated protein kinase 14 / 0.730
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.729
4fc0 0T2Serine/threonine-protein kinase B-raf 2.7.11.1 0.720
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.720
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.718
3gcu R48Mitogen-activated protein kinase 14 / 0.716
3hv4 L51Mitogen-activated protein kinase 14 / 0.710
3nnx EDDMitogen-activated protein kinase 14 / 0.707
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.705
4u0i 0LIMast/stem cell growth factor receptor Kit 2.7.10.1 0.704
3p5k P5KMitogen-activated protein kinase 14 / 0.698
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.693
1w82 L10Mitogen-activated protein kinase 14 / 0.692
3gcq 1BUMitogen-activated protein kinase 14 / 0.689
3hv3 R49Mitogen-activated protein kinase 14 / 0.689
3b2w 9NHTyrosine-protein kinase Lck 2.7.10.2 0.685
3oc1 BMUMitogen-activated protein kinase 14 / 0.685
1kv1 BMUMitogen-activated protein kinase 14 / 0.682
3gi3 B10Mitogen-activated protein kinase 14 / 0.680
3tub FPUTyrosine-protein kinase SYK 2.7.10.2 0.678
2hz0 GINTyrosine-protein kinase ABL1 2.7.10.2 0.675
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.675
3nnw EDDMitogen-activated protein kinase 14 / 0.673
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.672
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.671
2rl5 2RLVascular endothelial growth factor receptor 2 2.7.10.1 0.667
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.666
2puu G2GMitogen-activated protein kinase 14 / 0.665
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.663
3hv7 1AUMitogen-activated protein kinase 14 / 0.663
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.663
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.662
3uvr 06FMitogen-activated protein kinase 14 / 0.660
3p7c P7CMitogen-activated protein kinase 14 / 0.659
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.655
4ksp 1SUSerine/threonine-protein kinase B-raf 2.7.11.1 0.652
3o8t BMUMitogen-activated protein kinase 14 / 0.651
3p7b P7BMitogen-activated protein kinase 14 / 0.651
3o8u BMUMitogen-activated protein kinase 14 / 0.650