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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5h86 BCO Histone acetyltransferase KAT2A 2.3.1.48

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5h86 BCOHistone acetyltransferase KAT2A 2.3.1.48 1.292
5h84 1VUHistone acetyltransferase KAT2A 2.3.1.48 1.150
1z4r ACOHistone acetyltransferase KAT2A 2.3.1.48 1.109
1qsr ACOHAT A1 / 0.938
1qsn COAHAT A1 / 0.909
1pua COAHAT A1 / 0.882
2ou2 ACOHistone acetyltransferase KAT5 / 0.860
1kuv CA5Serotonin N-acetyltransferase / 0.843
1kux CA3Serotonin N-acetyltransferase / 0.813
5kf9 ACOPredicted acetyltransferase / 0.812
5kf8 ACOPredicted acetyltransferase / 0.811
5kgh ACOPredicted acetyltransferase / 0.809
5kf1 ACOPredicted acetyltransferase / 0.791
5kgp ACOPredicted acetyltransferase / 0.784
1kuy COTSerotonin N-acetyltransferase / 0.781
1pu9 COAHAT A1 / 0.780
5kf2 ACOPredicted acetyltransferase / 0.772
1mja COAHistone acetyltransferase ESA1 / 0.766
1fy7 COAHistone acetyltransferase ESA1 / 0.762
1mjb ACOHistone acetyltransferase ESA1 / 0.761
1m1d LYXHAT A1 / 0.756
1mj9 COAHistone acetyltransferase ESA1 / 0.753
2r8v ACOAmino-acid acetyltransferase / 0.753
1cm0 COAHistone acetyltransferase KAT2B 2.3.1.48 0.752
2q4v ACODiamine acetyltransferase 2 2.3.1.57 0.750
2giv ACOHistone acetyltransferase KAT8 / 0.748
2jev NHQDiamine acetyltransferase 1 / 0.748
5kgj ACOPredicted acetyltransferase / 0.748
4ag7 COAGlucosamine 6-phosphate N-acetyltransferase / 0.746
3d2m COAAmino-acid acetyltransferase / 0.741
1i12 ACOGlucosamine 6-phosphate N-acetyltransferase / 0.740
2c27 ACOMycothiol acetyltransferase 2.3.1.189 0.737
5kf1 COAPredicted acetyltransferase / 0.734
2vxk COAGlucosamine 6-phosphate acetyltransferase, putative / 0.733
4kvx ACON-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.733
2ozu ACOHistone acetyltransferase KAT6A / 0.732
2vqy ACOAAC(6')-Ib / 0.732
3bj7 COADiamine acetyltransferase 1 / 0.732
3vwe COAAlpha-tubulin N-acetyltransferase 1 / 0.730
1ib1 COTSerotonin N-acetyltransferase / 0.727
4lx9 ACON-alpha-acetyltransferase 2.3.1 0.727
2rc4 ACOHistone acetyltransferase KAT6A / 0.726
2x7b COAN-alpha-acetyltransferase 2.3.1 0.723
3to6 LYS_CMCHistone acetyltransferase ESA1 / 0.721
4r3k COAN-alpha-acetyltransferase 2.3.1 0.721
1wwz ACOUncharacterized protein / 0.719
4hkf ACOAlpha-tubulin N-acetyltransferase 1 / 0.716
5c88 COAN-alpha-acetyltransferase / 0.716
2prb COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.715
1p0h ACOMycothiol acetyltransferase 2.3.1.189 0.713
2jdd ACOProbable acetyltransferase / 0.712
2fxf ACODiamine acetyltransferase 1 / 0.709
3gy9 COAGCN5-related N-acetyltransferase / 0.707
3gya COAGCN5-related N-acetyltransferase / 0.707
2bsw CAOProbable acetyltransferase / 0.706
2y0m ACOHistone acetyltransferase KAT8 / 0.704
2zpa ACOtRNA(Met) cytidine acetyltransferase TmcA / 0.702
1qsm ACOHistone acetyltransferase HPA2 / 0.698
4ua3 COAN-alpha-acetyltransferase 40 2.3.1 0.698
2ob0 ACON-alpha-acetyltransferase 50 / 0.697
5kf2 COAPredicted acetyltransferase / 0.692
3te4 ACODopamine N-acetyltransferase / 0.691
3r96 ACOMccE protein / 0.688
5kf8 COAPredicted acetyltransferase / 0.686
4b13 NHWGlycylpeptide N-tetradecanoyltransferase / 0.684
1tiq COASpermidine/spermine N(1)-acetyltransferase / 0.682
1j4j ACOAcetyltransferase 2.3.1 0.681
2jdc CAOProbable acetyltransferase / 0.681
3exn ACOProbable acetyltransferase / 0.681
3s6f COAUncharacterized protein / 0.681
4mxe ACON-acetyltransferase ESCO1 2.3.1 0.681
2cns ACORibosomal-protein-alanine acetyltransferase / 0.679
3pgp ACOUncharacterized protein / 0.677
4qvt ACOAcetyltransferase YpeA 2.3.1 0.677
2bei ACODiamine acetyltransferase 2 2.3.1.57 0.676
1v0c ACOAAC(6')-Ib / 0.675
2vbq BSJAminoglycoside N(6')-acetyltransferase type 1 / 0.675
4u9z COAAlpha-tubulin N-acetyltransferase 1 / 0.675
1ozp ACOMycothiol acetyltransferase 2.3.1.189 0.674
1s3z COAAminoglycoside N(6')-acetyltransferase type 1 / 0.673
1ghe ACOAcetyltransferase 2.3.1 0.667
4u9v ACON-alpha-acetyltransferase 40 2.3.1 0.667
1s7n COAAcetyl transferase / 0.666
2ft0 ACOdTDP-fucosamine acetyltransferase / 0.666
2psw COAN-alpha-acetyltransferase 50 / 0.665
4xnh ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.665
5ag7 MYAGlycylpeptide N-tetradecanoyltransferase / 0.665
4kub COAUncharacterized protein / 0.663
1p0h COAMycothiol acetyltransferase 2.3.1.189 0.662
2a4n COAAac(6')-Ii protein / 0.662
5kf9 COAPredicted acetyltransferase / 0.662
4cry ACOPanD regulatory factor / 0.658
4crz ACOPanD regulatory factor / 0.658
4cs0 ACOPanD regulatory factor / 0.658
4zm6 ACON-acetyl-beta-D glucosaminidase / 0.658
3r95 ACOMccE protein / 0.657
3cz7 ACOHistone acetyltransferase RTT109 2.3.1.48 0.655
2qir COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.650