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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5eyu NAD Betaine-aldehyde dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5eyu NADBetaine-aldehyde dehydrogenase / 1.114
5ez4 NADBetaine-aldehyde dehydrogenase / 1.065
5dib NADBetaine-aldehyde dehydrogenase / 0.938
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.825
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.794
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.768
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.744
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.739
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.715
4pxl NADAldehyde dehydrogenase3 / 0.711
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.709
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.707
4pt0 NADAldehyde dehydrogenase / 0.706
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.705
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.704
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.703
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.703
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.702
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.700
4f3x NADPutative aldehyde dehydrogenase / 0.699
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.698
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.697
3iwj NADAminoaldehyde dehydrogenase / 0.696
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.689
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.683
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.683
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.682
2xdr NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.682
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.680
4nmj NAPAldehyde dehydrogenase / 0.680
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.678
4h73 NDPAldehyde dehydrogenase / 0.670
4i8q NADPutative betaine aldehyde dehyrogenase / 0.665
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.661
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.661
4pt3 NDPAldehyde dehydrogenase / 0.660
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.657
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.657
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.655
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.653
3haz NADBifunctional protein PutA / 0.652
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.650