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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ein NAP [LysW]-L-2-aminoadipate 6-phosphate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 1.213
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 1.083
2i3g NAPN-acetyl-gamma-glutamyl-phosphate reductase 1.2.1.38 0.832
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.790
4dpl NAPMalonyl-CoA reductase 1.2.1.75 0.763
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.761
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.759
1zh8 NAPUncharacterized protein / 0.757
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.757
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.753
3a14 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.740
3tri NAPPyrroline-5-carboxylate reductase / 0.735
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.732
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.730
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.726
2jcv NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.722
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.714
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.711
1i36 NAPConserved protein / 0.709
3ras NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.707
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.705
3f3s NADLambda-crystallin homolog / 0.704
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.700
2vq3 NAPMetalloreductase STEAP3 / 0.698
3hwr NDP2-dehydropantoate 2-reductase / 0.697
5bsg NAPPyrroline-5-carboxylate reductase / 0.697
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.695
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.694
2vhx NADAlanine dehydrogenase 1.4.1.1 0.691
3anl NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.691
3anm NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.691
3ggp NADPrephenate dehydrogenase / 0.690
3ikt NADRedox-sensing transcriptional repressor Rex / 0.690
4o59 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.690
5bsf NADPyrroline-5-carboxylate reductase / 0.690
1vi2 NADQuinate/shikimate dehydrogenase / 0.689
4o63 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.689
1x7g NAPPutative ketoacyl reductase 1.3.1 0.686
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.686
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.685
3hja NADGlyceraldehyde-3-phosphate dehydrogenase / 0.685
3keo NADRedox-sensing transcriptional repressor Rex / 0.683
4bmv NAPShort-chain dehydrogenase / 0.683
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.682
1gl3 NDPAspartate-semialdehyde dehydrogenase / 0.682
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 0.682
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.681
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.681
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.680
2yjz NAPMetalloreductase STEAP4 1.16.1 0.680
3zcx NADGlyceraldehyde-3-phosphate dehydrogenase / 0.680
4xyb NDPFormate dehydrogenase / 0.679
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 0.678
2rcy NAPPyrroline-5-carboxylate reductase / 0.678
4xgi NADGlutamate dehydrogenase / 0.678
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.676
2d2i NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.675
5a02 NAPGlucose-fructose oxidoreductase / 0.675
5aq1 NDPGlucose-6-phosphate 1-dehydrogenase / 0.675
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.674
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.673
2jd1 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.673
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.673
1o9b NAIQuinate/shikimate dehydrogenase / 0.672
2vyv NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.672
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.672
1cf2 NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.671
1c1d NAIPhenylalanine dehydrogenase / 0.669
1n7g NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.669
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.668
4tqg NDPPutative dTDP-d-glucose 4 6-dehydratase / 0.668
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.667
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.666
3adp NAILambda-crystallin 1.1.1.45 0.665
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.665
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.665
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.664
2g82 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.664
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.664
4xqc NADHomospermidine synthase 2.5.1.44 0.664
3rbv NAPSugar 3-ketoreductase / 0.663
4xrg NADHomospermidine synthase 2.5.1.44 0.663
1rm3 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.662
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.662
4aic NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.662
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.661
3t4e NADQuinate/shikimate dehydrogenase / 0.661
4b8w NAPGDP-L-fucose synthase 1.1.1.271 0.661
1rm4 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.660
2ahr NAPPyrroline-5-carboxylate reductase / 0.660
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.659
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.659
2jcx NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.659
4boy NADGlyceraldehyde-3-phosphate dehydrogenase / 0.659
4dbz NDPPutative ketoacyl reductase 1.3.1 0.659
1szj NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.658
3b20 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.658
3wfj NAD2-dehydropantoate 2-reductase / 0.658
2b4r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.657
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.657
1vc2 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
3q3c NADNAD-dependent L-serine dehydrogenase / 0.656
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.655
2jd0 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.655
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.654
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.654
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.653
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.653
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.653
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.653
1guy NADMalate dehydrogenase / 0.652
2c29 NAPDihydroflavonol 4-reductase / 0.652
4xb1 NDP319aa long hypothetical homoserine dehydrogenase / 0.651
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.650
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.650