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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5e92 ANP TGF-beta receptor type-2 2.7.11.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5e92 ANPTGF-beta receptor type-2 2.7.11.30 1.187
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.981
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.971
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.970
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.968
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.967
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.958
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.935
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.926
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.905
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.904
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.869
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.866
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.865
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.862
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.861
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.861
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.859
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.856
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.856
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.853
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.853
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.849
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.848
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.833
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.827
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.827
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.826
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.825
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.823
4dee ADPAurora kinase A 2.7.11.1 0.818
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.812
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.811
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.808
4ysj ADPCalmodulin-like domain protein kinase / 0.801
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.798
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.796
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.796
5dt3 ATPAurora kinase A 2.7.11.1 0.795
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.794
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.794
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.793
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.792
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.791
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.788
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.787
1cm8 ANPMitogen-activated protein kinase 12 / 0.785
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.785
2pyw ADPMethylthioribose kinase 2.7.1.100 0.784
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.783
4ceg ADPAurora kinase A 2.7.11.1 0.781
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.780
4qny ANPMitogen activated protein kinase, putative / 0.780
5dn3 ATPAurora kinase A 2.7.11.1 0.778
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.776
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.776
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.775
1mq4 ADPAurora kinase A 2.7.11.1 0.774
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.772
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.772
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.772
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.767
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.766
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.763
3ori AGSSerine/threonine protein kinase / 0.762
4utd ACPAurora kinase A 2.7.11.1 0.762
3cly ACPFibroblast growth factor receptor 2 / 0.761
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.760
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.760
3c50 ADPRhodopsin kinase / 0.758
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.756
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.756
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.754
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
5dos ATPAurora kinase A 2.7.11.1 0.752
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.747
5drd ATPAurora kinase A 2.7.11.1 0.746
4ffr ATPUncharacterized protein / 0.740
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.740
5iqb GNPBifunctional AAC/APH 2.3.1 0.740
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.738
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.738
5eg3 ACPFibroblast growth factor receptor 2 / 0.738
2pzp ACPFibroblast growth factor receptor 2 / 0.734
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.734
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.732
2py3 ACPFibroblast growth factor receptor 2 / 0.732
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.732
5dr2 ATPAurora kinase A 2.7.11.1 0.732
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.730
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.730
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.729
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.729
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.728
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.727
3c4z ADPRhodopsin kinase / 0.727
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.727
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.727
4ork GDPBifunctional AAC/APH 2.3.1 0.727
5ce3 ADPProtein kinase YopO / 0.727
2pui ADPMethylthioribose kinase 2.7.1.100 0.725
5dnr ATPAurora kinase A 2.7.11.1 0.725
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.724
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.724
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.724
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.721
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.720
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.718
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.718
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.717
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.717
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.716
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.715
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.714
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.714
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
3orm AGSSerine/threonine protein kinase / 0.714
2pz5 ACPFibroblast growth factor receptor 2 / 0.712
2x0q ATPAlcaligin biosynthesis protein / 0.712
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.711
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.711
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.711
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.710
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
3tdw GDPGentamicin resistance protein / 0.710
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
4o1p ANPRibonuclease L / 0.710
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.710
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.707
1ol6 ATPAurora kinase A 2.7.11.1 0.706
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.704
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.703
5dt4 ATPAurora kinase A 2.7.11.1 0.703
1ol5 ADPAurora kinase A 2.7.11.1 0.702
2pup ADPMethylthioribose kinase 2.7.1.100 0.702
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.702
1m0w ANPGlutathione synthetase 6.3.2.3 0.701
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.700
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.700
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.699
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.699
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.699
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.698
5byl GCPBifunctional AAC/APH 2.3.1 0.698
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.697
4xlv ACPInsulin receptor 2.7.10.1 0.697
2dwb ANPAurora kinase A 2.7.11.1 0.695
3rv4 ADPBiotin carboxylase 6.3.4.14 0.694
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
2pul ACPMethylthioribose kinase 2.7.1.100 0.693
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.693
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.693
2pun ACPMethylthioribose kinase 2.7.1.100 0.692
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.690
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.689
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.689
4n57 ADPAPH(2'')-Id / 0.688
2vqd AP2Biotin carboxylase 6.3.4.14 0.687
4bn1 ADPAurora kinase A 2.7.11.1 0.687
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.687
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.686
4ffl ADPUncharacterized protein / 0.686
5iqf GDPBifunctional AAC/APH 2.3.1 0.686
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.684
5iqh GNPBifunctional AAC/APH 2.3.1 0.684
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.683
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.683
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.683
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.682
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.682
3llt ANPProtein serine/threonine kinase-1 / 0.680
3t8o ATPRhodopsin kinase / 0.680
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.680
2wtk ANPSTE20-related kinase adapter protein alpha / 0.678
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.676
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.676
2hgs ADPGlutathione synthetase 6.3.2.3 0.674
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.674
3bu5 ATPInsulin receptor 2.7.10.1 0.674
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.674
4j98 ACPFibroblast growth factor receptor 2 / 0.673
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.672
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.671
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.671
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.671
5ckw ANPUncharacterized protein / 0.671
3wo0 ADPAlanine--anticapsin ligase / 0.670
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.669
4q5h ANPProtein kinase OspG 2.7 0.669
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.668
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.668
3nie ANPMitogen-activated protein kinase / 0.668
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.668
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.667
4o0u ADNAurora kinase A 2.7.11.1 0.666
2yaa ATPDeath-associated protein kinase 2 / 0.665
5iqa GNPBifunctional AAC/APH 2.3.1 0.665
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.664
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.663
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.662
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.662
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.662
3oro AGSSerine/threonine protein kinase / 0.661
3ort AGSSerine/threonine protein kinase / 0.661
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.660
4o0w ADNAurora kinase A 2.7.11.1 0.659
2wqe ADPAurora kinase A 2.7.11.1 0.658
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4o4e ATPKinase / 0.658
4o4f ATPKinase / 0.658
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.657
4zgn ATPCell division cycle protein 123 / 0.656
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.656
3c4w ATPRhodopsin kinase / 0.655
4ffm ADPUncharacterized protein / 0.655
2uvy GVIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.652
4tlc AGSCircadian clock protein kinase KaiC 2.7.11.1 0.652
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.652
1px2 ATPSynapsin-1 / 0.651
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.651
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.651
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650