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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5dt4 ATP Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5dt4 ATPAurora kinase A 2.7.11.1 0.923
5dos ATPAurora kinase A 2.7.11.1 0.880
5dn3 ATPAurora kinase A 2.7.11.1 0.833
5dnr ATPAurora kinase A 2.7.11.1 0.822
5dt3 ATPAurora kinase A 2.7.11.1 0.815
1mq4 ADPAurora kinase A 2.7.11.1 0.804
5drd ATPAurora kinase A 2.7.11.1 0.803
3c4z ADPRhodopsin kinase / 0.799
4dee ADPAurora kinase A 2.7.11.1 0.795
5dr2 ATPAurora kinase A 2.7.11.1 0.788
4utd ACPAurora kinase A 2.7.11.1 0.785
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.780
4ceg ADPAurora kinase A 2.7.11.1 0.779
2dwb ANPAurora kinase A 2.7.11.1 0.775
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.771
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.769
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.769
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.767
3t8o ATPRhodopsin kinase / 0.763
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.758
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.758
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.754
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.754
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.750
3qc9 ADPRhodopsin kinase / 0.748
4xlv ACPInsulin receptor 2.7.10.1 0.746
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.745
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.744
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.743
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.742
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.742
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.740
3c50 ADPRhodopsin kinase / 0.739
2pyw ADPMethylthioribose kinase 2.7.1.100 0.738
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.737
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.733
2pup ADPMethylthioribose kinase 2.7.1.100 0.729
1ol5 ADPAurora kinase A 2.7.11.1 0.728
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.728
1ol6 ATPAurora kinase A 2.7.11.1 0.727
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.727
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.726
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.725
3c4w ATPRhodopsin kinase / 0.724
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
4ysj ADPCalmodulin-like domain protein kinase / 0.724
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.723
2olc ADPMethylthioribose kinase 2.7.1.100 0.722
3llt ANPProtein serine/threonine kinase-1 / 0.722
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.721
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.720
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.719
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.718
2pui ADPMethylthioribose kinase 2.7.1.100 0.718
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.716
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.714
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.714
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.713
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.711
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.711
3bu5 ATPInsulin receptor 2.7.10.1 0.710
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.710
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.709
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.708
4bn1 ADPAurora kinase A 2.7.11.1 0.708
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.706
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.703
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.702
4qny ANPMitogen activated protein kinase, putative / 0.701
1cm8 ANPMitogen-activated protein kinase 12 / 0.699
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.697
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.696
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.695
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.694
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.693
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.692
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.691
2zdg ADPD-alanine--D-alanine ligase / 0.691
3nie ANPMitogen-activated protein kinase / 0.691
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
2yaa ATPDeath-associated protein kinase 2 / 0.690
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.690
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.690
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.689
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.689
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
3c4x ATPRhodopsin kinase / 0.688
4o0u ADNAurora kinase A 2.7.11.1 0.688
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
5ce3 ADPProtein kinase YopO / 0.686
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.684
3pff ADPATP-citrate synthase 2.3.3.8 0.684
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.684
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.683
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.681
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.681
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.680
3cly ACPFibroblast growth factor receptor 2 / 0.679
4ork GDPBifunctional AAC/APH 2.3.1 0.679
1u54 ACPActivated CDC42 kinase 1 / 0.678
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.678
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.678
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.678
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.677
2pul ACPMethylthioribose kinase 2.7.1.100 0.677
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.677
3rv4 ADPBiotin carboxylase 6.3.4.14 0.677
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.677
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.676
4c3p ACPAurora kinase A 2.7.11.1 0.676
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.676
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.675
4ix5 ANPUncharacterized protein / 0.675
2pun ACPMethylthioribose kinase 2.7.1.100 0.674
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.674
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.674
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.674
1ol7 ADPAurora kinase A 2.7.11.1 0.672
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.672
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.670
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.670
4c3r ACPAurora kinase A 2.7.11.1 0.669
5l8l ADPAurora kinase A 2.7.11.1 0.669
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.668
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.667
4lv8 ADPRhoptry protein 5 C / 0.667
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.666
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.666
5ckw ANPUncharacterized protein / 0.666
5l8j ADPAurora kinase A 2.7.11.1 0.665
2vgo AD5Aurora kinase B-A 2.7.11.1 0.664
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.664
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.664
4fhp UTPTerminal uridylyltransferase cid1 / 0.664
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.663
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.662
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
3oro AGSSerine/threonine protein kinase / 0.662
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.662
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.662
4fh5 UTPTerminal uridylyltransferase cid1 / 0.662
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
1fq1 ATPCyclin-dependent kinase 2 2.7.11.22 0.661
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.661
3q5i ANPProtein kinase, putative / 0.661
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.661
5eg3 ACPFibroblast growth factor receptor 2 / 0.661
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.660
3tdw GDPGentamicin resistance protein / 0.659
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.659
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.658
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.657
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.657
5iqb GNPBifunctional AAC/APH 2.3.1 0.657
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.656
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.655
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.655
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.655
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4o0w ADNAurora kinase A 2.7.11.1 0.655
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.655
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.654
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.654
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.653
5iqa GNPBifunctional AAC/APH 2.3.1 0.653
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.652
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.652
2wqe ADPAurora kinase A 2.7.11.1 0.650