Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5dt3 ATP Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5dt3 ATPAurora kinase A 2.7.11.1 0.996
5dn3 ATPAurora kinase A 2.7.11.1 0.948
4dee ADPAurora kinase A 2.7.11.1 0.923
5dr2 ATPAurora kinase A 2.7.11.1 0.919
5drd ATPAurora kinase A 2.7.11.1 0.878
4ceg ADPAurora kinase A 2.7.11.1 0.876
4utd ACPAurora kinase A 2.7.11.1 0.856
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.852
5dnr ATPAurora kinase A 2.7.11.1 0.851
1mq4 ADPAurora kinase A 2.7.11.1 0.846
5dos ATPAurora kinase A 2.7.11.1 0.845
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.834
3c4z ADPRhodopsin kinase / 0.824
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.824
4bn1 ADPAurora kinase A 2.7.11.1 0.817
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.816
5dt4 ATPAurora kinase A 2.7.11.1 0.815
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.814
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.810
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.806
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.804
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.804
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.803
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.802
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.801
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.800
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.795
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.794
2dwb ANPAurora kinase A 2.7.11.1 0.793
4ysj ADPCalmodulin-like domain protein kinase / 0.792
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.789
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.788
3c50 ADPRhodopsin kinase / 0.788
2pui ADPMethylthioribose kinase 2.7.1.100 0.787
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.780
4qny ANPMitogen activated protein kinase, putative / 0.780
4xlv ACPInsulin receptor 2.7.10.1 0.780
2pyw ADPMethylthioribose kinase 2.7.1.100 0.779
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.776
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.771
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.771
3qc9 ADPRhodopsin kinase / 0.770
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.769
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.769
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.768
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.768
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.767
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.767
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.765
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.763
1ol5 ADPAurora kinase A 2.7.11.1 0.762
3bu5 ATPInsulin receptor 2.7.10.1 0.761
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.757
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.756
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.753
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.753
5ce3 ADPProtein kinase YopO / 0.753
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.752
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.751
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.751
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.750
1ol6 ATPAurora kinase A 2.7.11.1 0.748
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.748
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.747
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.747
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.746
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.745
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.745
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.743
2olc ADPMethylthioribose kinase 2.7.1.100 0.740
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.740
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.739
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.737
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.737
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.736
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.736
3cly ACPFibroblast growth factor receptor 2 / 0.735
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.735
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.735
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.733
4gyi ADPUncharacterized protein / 0.732
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.732
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.731
2pup ADPMethylthioribose kinase 2.7.1.100 0.731
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.731
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.727
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.725
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.724
3t8o ATPRhodopsin kinase / 0.724
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.723
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.723
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.723
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.722
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.721
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.721
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.720
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.719
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.718
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.718
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.717
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.715
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.711
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.709
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.709
5eg3 ACPFibroblast growth factor receptor 2 / 0.709
3c4w ATPRhodopsin kinase / 0.707
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
2pml ANPUncharacterized protein / 0.706
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.706
4o0u ADNAurora kinase A 2.7.11.1 0.706
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.706
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.704
3ori AGSSerine/threonine protein kinase / 0.702
2py3 ACPFibroblast growth factor receptor 2 / 0.701
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.701
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.700
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.698
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.696
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.696
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.695
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.693
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
2pz5 ACPFibroblast growth factor receptor 2 / 0.692
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.692
2yaa ATPDeath-associated protein kinase 2 / 0.692
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.691
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.690
4zgn ATPCell division cycle protein 123 / 0.690
1m0w ANPGlutathione synthetase 6.3.2.3 0.689
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.689
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.688
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.686
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.686
4ix5 ANPUncharacterized protein / 0.686
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.685
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.684
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.683
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.682
1ol7 ADPAurora kinase A 2.7.11.1 0.682
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
3nie ANPMitogen-activated protein kinase / 0.681
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.681
1cm8 ANPMitogen-activated protein kinase 12 / 0.680
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.680
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.680
2pzp ACPFibroblast growth factor receptor 2 / 0.679
5iqa GNPBifunctional AAC/APH 2.3.1 0.677
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.676
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.676
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.676
4ork GDPBifunctional AAC/APH 2.3.1 0.676
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.675
3r5f ATPD-alanine--D-alanine ligase / 0.675
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.675
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.674
4o1p ANPRibonuclease L / 0.674
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.673
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.673
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.672
4c3r ACPAurora kinase A 2.7.11.1 0.672
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
5iqi GNPBifunctional AAC/APH 2.3.1 0.672
3llt ANPProtein serine/threonine kinase-1 / 0.671
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.671
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.669
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.669
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.669
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.669
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.668
2pul ACPMethylthioribose kinase 2.7.1.100 0.668
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.668
4q5h ANPProtein kinase OspG 2.7 0.668
5iqe GNPBifunctional AAC/APH 2.3.1 0.668
1u54 ACPActivated CDC42 kinase 1 / 0.667
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.666
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.666
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.666
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.665
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.665
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.663
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.663
3oro AGSSerine/threonine protein kinase / 0.663
3rv4 ADPBiotin carboxylase 6.3.4.14 0.663
2j9g ADPBiotin carboxylase 6.3.4.14 0.662
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.662
4c3p ACPAurora kinase A 2.7.11.1 0.662
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.662
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
2pun ACPMethylthioribose kinase 2.7.1.100 0.661
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4lv8 ADPRhoptry protein 5 C / 0.661
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.661
4o0s ADNAurora kinase A 2.7.11.1 0.660
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.660
5iqh GNPBifunctional AAC/APH 2.3.1 0.660
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.659
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.659
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.658
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.658
4o0w ADNAurora kinase A 2.7.11.1 0.658
5iqb GNPBifunctional AAC/APH 2.3.1 0.658
1px2 ATPSynapsin-1 / 0.657
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.657
3tdw GDPGentamicin resistance protein / 0.657
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.657
4n57 ADPAPH(2'')-Id / 0.657
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.656
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.656
5iqf GDPBifunctional AAC/APH 2.3.1 0.656
5l6w AGSLIM domain kinase 1 2.7.11.1 0.656
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.655
3g6w GTPUracil phosphoribosyltransferase 2.4.2.9 0.655
5iqd GNPBifunctional AAC/APH 2.3.1 0.655
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.654
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.652
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.652
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.652
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.652
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.650
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.650