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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5dpv SKE Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5dpv SKEAurora kinase A 2.7.11.1 0.945
5dr9 SKEAurora kinase A 2.7.11.1 0.875
5dr6 SKEAurora kinase A 2.7.11.1 0.857
5dt0 SKEAurora kinase A 2.7.11.1 0.840
4dea NHIAurora kinase A 2.7.11.1 0.721
3ama SKEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.702
3uo5 0BXAurora kinase A 2.7.11.1 0.702
2wmw ZYWSerine/threonine-protein kinase Chk1 2.7.11.1 0.658