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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5dnr ATP Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5dnr ATPAurora kinase A 2.7.11.1 0.977
5dr2 ATPAurora kinase A 2.7.11.1 0.855
5dn3 ATPAurora kinase A 2.7.11.1 0.854
5dt3 ATPAurora kinase A 2.7.11.1 0.851
5dos ATPAurora kinase A 2.7.11.1 0.835
5drd ATPAurora kinase A 2.7.11.1 0.822
5dt4 ATPAurora kinase A 2.7.11.1 0.822
1mq4 ADPAurora kinase A 2.7.11.1 0.802
4ceg ADPAurora kinase A 2.7.11.1 0.801
4dee ADPAurora kinase A 2.7.11.1 0.789
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.785
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.781
4utd ACPAurora kinase A 2.7.11.1 0.779
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.770
3c4z ADPRhodopsin kinase / 0.765
2dwb ANPAurora kinase A 2.7.11.1 0.763
3qc9 ADPRhodopsin kinase / 0.763
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.763
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.761
3c50 ADPRhodopsin kinase / 0.760
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.754
4bn1 ADPAurora kinase A 2.7.11.1 0.753
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.751
1ol6 ATPAurora kinase A 2.7.11.1 0.750
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.749
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.748
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.747
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.746
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.744
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.742
4qny ANPMitogen activated protein kinase, putative / 0.740
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.739
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.735
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.731
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.730
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.730
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.727
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.727
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.725
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.725
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.724
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.723
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.723
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.721
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.721
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.720
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.719
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.716
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.714
3cly ACPFibroblast growth factor receptor 2 / 0.714
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.714
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.713
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.712
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
2pui ADPMethylthioribose kinase 2.7.1.100 0.711
2pyw ADPMethylthioribose kinase 2.7.1.100 0.711
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.710
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
1ol5 ADPAurora kinase A 2.7.11.1 0.709
2pup ADPMethylthioribose kinase 2.7.1.100 0.708
3t8o ATPRhodopsin kinase / 0.707
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.707
4ysj ADPCalmodulin-like domain protein kinase / 0.707
2olc ADPMethylthioribose kinase 2.7.1.100 0.705
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
4xlv ACPInsulin receptor 2.7.10.1 0.701
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.700
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.700
3c4w ATPRhodopsin kinase / 0.700
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.700
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.700
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.700
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.697
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.696
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.696
3oro AGSSerine/threonine protein kinase / 0.696
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
2pun ACPMethylthioribose kinase 2.7.1.100 0.695
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.693
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.690
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.689
3bu5 ATPInsulin receptor 2.7.10.1 0.688
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.687
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.686
1ol7 ADPAurora kinase A 2.7.11.1 0.685
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.685
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.685
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.684
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.684
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.683
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.683
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.683
2yaa ATPDeath-associated protein kinase 2 / 0.683
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.682
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.682
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.681
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.681
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.681
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.680
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.680
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.680
4gyi ADPUncharacterized protein / 0.680
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.679
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.679
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.678
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.678
5l8k ADPAurora kinase A 2.7.11.1 0.678
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.676
4zgn ATPCell division cycle protein 123 / 0.676
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.675
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
4o0u ADNAurora kinase A 2.7.11.1 0.675
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.674
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.674
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.673
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.673
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.671
3a8w ATPProtein kinase C iota type 2.7.11.13 0.671
5ce3 ADPProtein kinase YopO / 0.671
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.670
2zdg ADPD-alanine--D-alanine ligase / 0.670
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.670
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.670
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
3nie ANPMitogen-activated protein kinase / 0.667
3ori AGSSerine/threonine protein kinase / 0.667
4ix5 ANPUncharacterized protein / 0.666
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.665
3ork AGSSerine/threonine protein kinase / 0.664
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.664
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
1cm8 ANPMitogen-activated protein kinase 12 / 0.663
2pul ACPMethylthioribose kinase 2.7.1.100 0.662
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.662
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
4ork GDPBifunctional AAC/APH 2.3.1 0.662
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.661
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.661
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.661
4fu0 ADPD-alanine--D-alanine ligase / 0.661
2vgo AD5Aurora kinase B-A 2.7.11.1 0.660
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.660
3tdw GDPGentamicin resistance protein / 0.659
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.659
4q5h ANPProtein kinase OspG 2.7 0.659
5iqh GNPBifunctional AAC/APH 2.3.1 0.659
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.658
5eg3 ACPFibroblast growth factor receptor 2 / 0.658
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.657
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.657
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.656
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.656
5iqi GNPBifunctional AAC/APH 2.3.1 0.656
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.655
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.655
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.654
1u54 ACPActivated CDC42 kinase 1 / 0.654
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3q5i ANPProtein kinase, putative / 0.654
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.653
4c3r ACPAurora kinase A 2.7.11.1 0.653
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.653
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.652
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.652
4o4f ATPKinase / 0.651
1fq1 ATPCyclin-dependent kinase 2 2.7.11.22 0.650
2pzp ACPFibroblast growth factor receptor 2 / 0.650
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.650
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.650
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.650
4o4e ATPKinase / 0.650