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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5dmz ADP Mitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.907
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.763
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.741
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.740
4n57 ADPAPH(2'')-Id / 0.735
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.731
5drd ATPAurora kinase A 2.7.11.1 0.709
4ceg ADPAurora kinase A 2.7.11.1 0.699
1mq4 ADPAurora kinase A 2.7.11.1 0.697
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.697
4ysj ADPCalmodulin-like domain protein kinase / 0.697
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.696
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.696
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.690
4lv8 ADPRhoptry protein 5 C / 0.689
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
5dos ATPAurora kinase A 2.7.11.1 0.688
5dt3 ATPAurora kinase A 2.7.11.1 0.688
4dee ADPAurora kinase A 2.7.11.1 0.686
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.686
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.685
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.685
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.683
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.683
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.682
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.681
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.680
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.677
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.676
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.674
2pyw ADPMethylthioribose kinase 2.7.1.100 0.673
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.673
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.672
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.669
2pup ADPMethylthioribose kinase 2.7.1.100 0.668
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.667
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.667
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.667
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.667
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.667
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.666
5ce3 ADPProtein kinase YopO / 0.664
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.663
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.661
3ort AGSSerine/threonine protein kinase / 0.657
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.656
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.655
4hne ADPPhosphatidylinositol 4-kinase type 2-alpha / 0.654
4utd ACPAurora kinase A 2.7.11.1 0.654
3c4z ADPRhodopsin kinase / 0.653
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.653
3ori AGSSerine/threonine protein kinase / 0.652
4ffl ADPUncharacterized protein / 0.652
5dt4 ATPAurora kinase A 2.7.11.1 0.652
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.652
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.651
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.650
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.650
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.650
3wo0 ADPAlanine--anticapsin ligase / 0.650