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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5cho FAD Flavin reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5cho FADFlavin reductase / 1.423
1rz1 FADPhenol 2-hydroxylase component B / 0.849
1rz0 FADPhenol 2-hydroxylase component B / 0.840
2ed4 FAD4-hydroxyphenylacetate 3-monooxygenase reductase component 1.5.1.36 0.797
4f07 FADStyrene monooxygenase component 2 / 0.792
4l82 FMNUncharacterized protein / 0.790
3e4v FMNUncharacterized protein / 0.774
4wqm FADToluene-4-monooxygenase electron transfer component 1.18.1.3 0.762
1cqx FADFlavohemoprotein / 0.756
2bn4 FADNADPH--cytochrome P450 reductase / 0.755
1amo FADNADPH--cytochrome P450 reductase / 0.751
3in6 FMNUncharacterized protein / 0.746
1i0s FMNFerric-chelate reductase (NAD(P)H) / 0.743
3rh7 FMNUncharacterized protein / 0.743
4fk8 FADFerredoxin--NADP reductase / 0.740
1usc FMNMonooxygenase / 0.739
2ok8 FADFerredoxin--NADP reductase, apicoplast / 0.731
1tll FADNitric oxide synthase, brain 1.14.13.39 0.725
2i02 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.725
3hjk FADVivid PAS protein VVD / 0.725
3bnk FMNFlavoredoxin / 0.721
2pia FMNPhthalate dioxygenase reductase / 0.719
4hj3 FMNLOV protein / 0.718
4hj4 FMNLOV protein / 0.718
1ib0 FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.716
1kqc FMNOxygen-insensitive NAD(P)H nitroreductase / 0.712
1n9l FMNPutative blue light receptor / 0.707
1pkv RBFRiboflavin synthase 2.5.1.9 0.707
2pd8 FADVivid PAS protein VVD / 0.706
2qdx FADFerredoxin--NADP+ reductase / 0.706
2bgj FADNADPH:ferredoxin reductase / 0.704
2ok7 FADFerredoxin--NADP reductase, apicoplast / 0.703
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.702
1a8p FADFerredoxin--NADP reductase / 0.701
1gvh FADFlavohemoprotein / 0.701
2eix FADNADH-cytochrome b5 reductase / 0.701
2vnj FADNADPH:ferredoxin reductase / 0.700
1umk FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.699
3d72 FADVivid PAS protein VVD / 0.698
3w5h FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.698
2bf4 FADNADPH--cytochrome P450 reductase / 0.696
4ees FMNPhototropin-2 2.7.11.1 0.696
3mzi FMNActivator of photopigment and puc expression / 0.695
1eje FMNProtein MTH_152 / 0.694
1ylu FMNOxygen-insensitive NAD(P)H nitroreductase / 0.694
3w2f FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.694
4eep FMNPhototropin-2 2.7.11.1 0.694
4wuj FMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy / 0.694
2bgi FADNADPH:ferredoxin reductase / 0.693
2jk6 FADTrypanothione reductase / 0.693
3klb FMNUncharacterized protein / 0.692
4dna FADProbable glutathione reductase / 0.692
4eer FMNPhototropin-2 2.7.11.1 0.691
2vnk FADNADPH:ferredoxin reductase / 0.689
3t50 FMNBlue-light-activated histidine kinase 2.7.13.3 0.689
2pr5 FMNBlue-light photoreceptor / 0.687
3a3b RBFLumazine protein / 0.686
1j9z FADNADPH--cytochrome P450 reductase / 0.685
3qe2 FADNADPH--cytochrome P450 reductase / 0.685
3w2e FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.685
4ylf FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog / 0.685
4b4d FADFerredoxin-NADP reductase / 0.684
1g63 FMNEpidermin decarboxylase 4.1.1 0.683
2wzv FMNNitroreductase NfnB / 0.682
2wzw FMNNitroreductase NfnB / 0.682
4j57 FADThioredoxin reductase 2 1.8.1.9 0.682
4rhe FMNFlavin prenyltransferase UbiX / 0.682
4eeu FMNPhototropin-2 2.7.11.1 0.681
2pd7 FADVivid PAS protein VVD / 0.680
4eet FMNPhototropin-2 2.7.11.1 0.680
5efw FMNNPH1-1 / 0.678
1krh FADBenzoate 1,2-dioxygenase electron transfer component 1.18.1.3 0.677
3qfc FADNADPH--cytochrome P450 reductase / 0.677
4hms FMNPhenazine biosynthesis protein PhzG 1.4 0.677
4k1x FADNADPH:ferredoxin reductase / 0.677
2i51 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.675
3crz FADFerredoxin--NADP+ reductase / 0.674
2g37 FADProline dehydrogenase / 0.673
1typ FADTrypanothione reductase 1.8.1.12 0.672
1v5e FADPyruvate oxidase / 0.672
3is2 FADVivid PAS protein VVD / 0.672
3qdl FMNOxygen-insensitive NADPH nitroreductase / 0.672
1ogi FADFerredoxin--NADP reductase 1.18.1.2 0.671
1sm4 FADFerredoxin--NADP reductase / 0.671
2j4d FADCryptochrome DASH, chloroplastic/mitochondrial / 0.670
2pdt FADVivid PAS protein VVD / 0.670
4hmw FMNPyridoxamine 5'-phosphate oxidase / 0.670
2iml FMNUncharacterized protein / 0.669
2z6c FMNPhototropin-1 2.7.11.1 0.668
3qvp FADGlucose oxidase 1.1.3.4 0.668
4hhd FMNPhototropin-1 2.7.11.1 0.668
4hnb FMNLOV protein / 0.668
1vfr FMNMajor NAD(P)H-flavin oxidoreductase 1.6.99 0.667
3qvr FADGlucose oxidase 1.1.3.4 0.666
1ger FADGlutathione reductase 1.8.1.7 0.665
1i7p FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.665
1ooq FMNOxygen-insensitive NAD(P)H nitroreductase / 0.665
4yxd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.665
1get FADGlutathione reductase 1.8.1.7 0.664
2byc FMNBlue-light receptor of the BLUF-family / 0.664
2ign FADPyranose 2-oxidase / 0.664
2tpr FADTrypanothione reductase 1.8.1.12 0.664
3eo8 FMNPutative nitroreductase / 0.664
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.663
4kuk RBFPutative blue-light photoreceptor / 0.663
4wf0 FMNNPH1-1 / 0.663
5af7 FADAcyl-CoA dehydrogenase / 0.663
2zbw FADFerredoxin--NADP reductase / 0.661
3pxv FMNNitroreductase / 0.661
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.661
1wv4 FMNPyridoxine/pyridoxamine 5'-phosphate oxidase / 0.660
2wp5 FADTrypanothione reductase / 0.660
3qfr FADNADPH--cytochrome P450 reductase / 0.660
3a3g DLZLumazine protein / 0.659
3bm1 FMNPutative NAD(P)H nitroreductase YdjA / 0.659
3q9t FAYUncharacterized protein / 0.659
5f12 FMNNAD(P)H dehydrogenase (quinone) / 0.659
2hq9 FADMll6688 protein / 0.658
3p8j FMNPentaerythritol tetranitrate reductase / 0.658
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.658
4x9n FADUncharacterized protein MG039 homolog / 0.658
3f03 FMNPentaerythritol tetranitrate reductase / 0.657
3r5y F42Uncharacterized protein / 0.657
4af6 FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.657
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.657
1e63 FADFerredoxin--NADP reductase 1.18.1.2 0.656
2cnd FADNitrate reductase [NADH] 1.7.1.1 0.656
2ohi FMNType A flavoprotein FprA 1 0.656
2ou5 FMNPyridoxamine 5'-phosphate oxidase-related FMN-binding protein / 0.656
3a20 FMNFMN-binding protein / 0.656
3ute FADUDP-galactopyranose mutase / 0.656
1fea FADTrypanothione reductase 1.8.1.12 0.655
2igo FADPyranose 2-oxidase / 0.655
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.655
3t2z FADSulfide-quinone reductase / 0.654
3vy2 FMNFMN-binding protein / 0.654
4j8p FMNFlavodoxin / 0.654
1ci0 FMNPyridoxamine 5'-phosphate oxidase 1.4.3.5 0.653
2hqm FADGlutathione reductase 1.8.1.7 0.653
2q7v FADThioredoxin reductase / 0.653
2v0u FMNNPH1-1 / 0.653
2v1a FMNNPH1-1 / 0.653
3ojw FADNADPH--cytochrome P450 reductase / 0.653
2o12 FMNChorismate synthase / 0.652
1np7 FADCryptochrome DASH / 0.651
1s4m LUMRiboflavin biosynthesis protein / 0.651
1ty9 FMNPhenazine biosynthesis protein PhzG 1.4 0.651
3a6r FMNFMN-binding protein / 0.651
3fmw FADOxygenase / 0.651
4j56 FADThioredoxin reductase 2 1.8.1.9 0.651
4ttc FMNIodotyrosine deiodinase 1 / 0.651
3a6q FMNFMN-binding protein / 0.650
3cox FADCholesterol oxidase 1.1.3.6 0.650
3ue6 FMNAureochrome1 / 0.650