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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5c93 ACP Two-component system histidine protein kinase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5c93 ACPTwo-component system histidine protein kinase / 1.090
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.681
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.673
3a0t ADPSensor histidine kinase / 0.672
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.666
4rpg GDUUDP-galactopyranose mutase 5.4.99.9 0.663
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.661
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4prx ADPDNA gyrase subunit B / 0.660
4jau ADPSensor histidine kinase / 0.656
4pl9 ADPEthylene receptor 1 / 0.656
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.655
1g8o U5PN-acetyllactosaminide alpha-1,3-galactosyltransferase / 0.652
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.651
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.651
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.651
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.651
1i58 ADPChemotaxis protein CheA 2.7.13.3 0.650
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.650
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.650
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.650