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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ap7 SVE Dual specificity protein kinase TTK 2.7.12.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5ap7 SVEDual specificity protein kinase TTK 2.7.12.1 1.220
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.710
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.704
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.686
2p33 J07Mitogen-activated protein kinase 10 2.7.11.24 0.670
4c4h 7RODual specificity protein kinase TTK 2.7.12.1 0.668
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.662
3i5z Z48Mitogen-activated protein kinase 1 2.7.11.24 0.660
3i4b Z48Glycogen synthase kinase-3 beta 2.7.11.26 0.658
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.657
1oir HDYCyclin-dependent kinase 2 2.7.11.22 0.655
4c4f 7CEDual specificity protein kinase TTK 2.7.12.1 0.655
4c4i X20Dual specificity protein kinase TTK 2.7.12.1 0.655
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.655
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.654
1oec AA2Fibroblast growth factor receptor 2 / 0.652
3cgo JNOMitogen-activated protein kinase 10 2.7.11.24 0.652