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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4zzj CNA NAD-dependent protein deacetylase sirtuin-1 3.5.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4zzj CNANAD-dependent protein deacetylase sirtuin-1 3.5.1 1.233
5d7q AR6NAD-dependent protein deacetylase sirtuin-2 3.5.1 0.806
5d7o AR6NAD-dependent protein deacetylase sirtuin-2 3.5.1 0.796
3d4b DZDNAD-dependent protein deacetylase / 0.795
5d7p AR6NAD-dependent protein deacetylase sirtuin-2 3.5.1 0.774
1m2h APRNAD-dependent protein deacylase 1 / 0.746
4bvb AR6NAD-dependent protein deacetylase sirtuin-3, mitochondrial 3.5.1 0.741
1m2j APRNAD-dependent protein deacylase 1 / 0.739
2b4y APRNAD-dependent protein deacylase sirtuin-5, mitochondrial / 0.731
4bvh AR6NAD-dependent protein deacetylase sirtuin-3, mitochondrial 3.5.1 0.730
1m2g APRNAD-dependent protein deacylase 1 / 0.723
4g1c CNANAD-dependent protein deacylase sirtuin-5, mitochondrial / 0.717
1m2k APRNAD-dependent protein deacylase 1 / 0.712
1yc2 NADNAD-dependent protein deacylase 2 / 0.705
1szc CNANAD-dependent protein deacetylase HST2 3.5.1 0.703
2qqf A1RNAD-dependent protein deacetylase HST2 3.5.1 0.692
2od7 A1RNAD-dependent protein deacetylase HST2 3.5.1 0.691
1s7g NADNAD-dependent protein deacylase 2 / 0.676
1yc2 APRNAD-dependent protein deacylase 2 / 0.655
1pow FADPyruvate oxidase 1.2.3.3 0.650
1s7g APRNAD-dependent protein deacylase 2 / 0.650