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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4zz7 NAD Methylmalonate-semialdehyde dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 1.101
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.758
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.754
4pz2 NADAldehyde dehydrogenase 2-6 / 0.733
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.726
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.712
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.704
2jg7 NADAntiquitin / 0.702
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.700
3b4w NADAldehyde dehydrogenase family protein / 0.700
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.699
4i3w NADAldehyde dehydrogenase (NAD+) / 0.696
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.695
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.695
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.694
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.693
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.687
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.687
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.684
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.683
4i8p NADAminoaldehyde dehydrogenase 1 / 0.680
4i8q NADPutative betaine aldehyde dehyrogenase / 0.680
4i3v NADAldehyde dehydrogenase (NAD+) / 0.679
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.673
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.672
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.672
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.666
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.662
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.661
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.659
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.658
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.658
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.655
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.654