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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4zwg DTP Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4zwg DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.234
4tnx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.077
4to4 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.071
4tnq TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.040
4to0 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.024
4tnz DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.013
4to3 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.009
4tnp DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.000
4qfx DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.977
4qfy DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.919
4to5 TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.906
4to6 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.902
4tnr DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.876
4tny DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.833
4bzc T8TDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.724
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.713
3orl AGSSerine/threonine protein kinase / 0.707
1yv5 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.684
3b05 IPEIsopentenyl-diphosphate delta-isomerase / 0.675
3ruq ADPChaperonin / 0.672
4kh0 ATPAspartate carbamoyltransferase regulatory chain {ECO:0000256|HAMAP-Rule:MF_00002} / 0.669
3law GNPRas-related protein Rab-7a / 0.664
3mhy ATPNitrogen regulatory protein P-II 1 / 0.663
4d03 NAPPhenylacetone monooxygenase 1.14.13.92 0.659
5exd TPPOxalate oxidoreductase subunit alpha / 0.658
5exd TPPOxalate oxidoreductase subunit beta / 0.658
3er9 3ATPoly(A) polymerase catalytic subunit 2.7.7.19 0.654
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.652
4bri UNPEctonucleoside triphosphate diphosphohydrolase I / 0.651
2pz8 APCNH(3)-dependent NAD(+) synthetase / 0.650