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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4zs4 ATP Myosin heavy chain kinase A 2.7.11.7

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.980
3lla ACPMyosin heavy chain kinase A 2.7.11.7 0.885
4zme ADNMyosin heavy chain kinase A 2.7.11.7 0.796
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.792
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.789
5e9e ANPMyosin heavy chain kinase A 2.7.11.7 0.740
1px2 ATPSynapsin-1 / 0.728
1pk8 ATPSynapsin-1 / 0.727
2r7n ADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.724
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.714
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.711
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.707
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.705
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.704
1iah ADPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.701
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.700
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.696
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.695
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.694
4ffr ATPUncharacterized protein / 0.693
3r5f ATPD-alanine--D-alanine ligase / 0.685
2vqd AP2Biotin carboxylase 6.3.4.14 0.682
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.682
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.681
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.681
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.679
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.679
4ffl ADPUncharacterized protein / 0.679
1ia9 ANPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.677
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.677
3eps ATPIsocitrate dehydrogenase kinase/phosphatase / 0.676
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.676
3tw6 ADPPyruvate carboxylase / 0.676
3g8d ADPBiotin carboxylase 6.3.4.14 0.675
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.675
3wnz ADPAlanine--anticapsin ligase / 0.674
3wo0 ADPAlanine--anticapsin ligase / 0.673
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.672
4iwx ADPRibosomal protein S6--L-glutamate ligase / 0.672
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.671
1mq4 ADPAurora kinase A 2.7.11.1 0.670
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.670
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.669
2xcl ANPPhosphoribosylamine--glycine ligase / 0.669
4o4f ATPKinase / 0.668
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.666
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.666
2j9g ADPBiotin carboxylase 6.3.4.14 0.664
3cvu FADRE11660p / 0.663
4ffm ADPUncharacterized protein / 0.663
4fu0 ADPD-alanine--D-alanine ligase / 0.662
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.660
2pul ACPMethylthioribose kinase 2.7.1.100 0.660
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.659
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.659
5c1o ANPD-alanine--D-alanine ligase / 0.659
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.657
2i8c ADPD-alanine--D-alanine ligase / 0.657
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.657
5dt4 ATPAurora kinase A 2.7.11.1 0.657
3cvy FADRE11660p / 0.655
4o4e ATPKinase / 0.654
2zdg ADPD-alanine--D-alanine ligase / 0.653
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.653
2hgs ADPGlutathione synthetase 6.3.2.3 0.652
2pui ADPMethylthioribose kinase 2.7.1.100 0.652
3akl ANPSerine/threonine-protein kinase CtkA 2.7.11.1 0.652
4bn1 ADPAurora kinase A 2.7.11.1 0.652
4gyi ADPUncharacterized protein / 0.652
2olc ADPMethylthioribose kinase 2.7.1.100 0.651
1ol5 ADPAurora kinase A 2.7.11.1 0.650
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.650
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.650
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.650