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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4z26 FAD Putative GMC-type oxidoreductase R135 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4z26 FADPutative GMC-type oxidoreductase R135 1 1.372
4z24 FADPutative GMC-type oxidoreductase R135 1 1.283
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.959
1cf3 FADGlucose oxidase 1.1.3.4 0.921
1gpe FADGlucose oxidase 1.1.3.4 0.888
3qvr FADGlucose oxidase 1.1.3.4 0.882
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.875
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.871
4ynt FDAGlucose oxidase, putative / 0.869
3t37 FADPyridoxine 4-oxidase / 0.863
3qvp FADGlucose oxidase 1.1.3.4 0.857
3q9t FAYUncharacterized protein / 0.851
3kpf FADPolyamine oxidase 1.5.3.14 0.819
3bi2 FADPolyamine oxidase FMS1 / 0.815
1h83 FADPolyamine oxidase 1.5.3.14 0.808
5hsa FASAlcohol oxidase 1 1.1.3.13 0.808
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.793
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.792
1gal FADGlucose oxidase 1.1.3.4 0.792
1rsg FADPolyamine oxidase FMS1 / 0.792
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.787
2uxx FAJLysine-specific histone demethylase 1A 1 0.787
2yg4 FADPutrescine oxidase / 0.785
4em4 FADCoenzyme A disulfide reductase / 0.784
4qi4 FADCellobiose dehydrogenase / 0.782
2yg5 FADPutrescine oxidase / 0.781
4yry FADGlutamate synthase, beta subunit / 0.781
3kkj FADRenalase / 0.776
3cnd FADPolyamine oxidase FMS1 / 0.774
2iw5 FADLysine-specific histone demethylase 1A 1 0.772
4qi5 FADCellobiose dehydrogenase / 0.772
2y48 FADLysine-specific histone demethylase 1A 1 0.771
4fwf FADLysine-specific histone demethylase 1B 1 0.770
4qi7 FADCellobiose dehydrogenase / 0.770
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.769
1h81 FADPolyamine oxidase 1.5.3.14 0.767
2dw4 FADLysine-specific histone demethylase 1A 1 0.765
2h94 FADLysine-specific histone demethylase 1A 1 0.765
3gyj FADCholesterol oxidase 1.1.3.6 0.763
3r9u FADThioredoxin reductase / 0.762
4xbf FADLysine-specific histone demethylase 1A 1 0.762
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.761
4fwj FADLysine-specific histone demethylase 1B 1 0.761
4gdp FADPolyamine oxidase FMS1 / 0.754
4u2s FDACholesterol oxidase 1.1.3.6 0.754
3rha FDAPutrescine oxidase / 0.753
2e1m FADL-glutamate oxidase / 0.752
3cox FADCholesterol oxidase 1.1.3.6 0.752
3gyi FADCholesterol oxidase 1.1.3.6 0.751
2zbw FADFerredoxin--NADP reductase / 0.750
4gur FADLysine-specific histone demethylase 1B 1 0.749
3ish FADThioredoxin reductase 1.8.1.9 0.747
2b9x FADPutative aminooxidase / 0.745
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.745
3jsk AHZThiamine thiazole synthase / 0.744
4hsu FADLysine-specific histone demethylase 1B 1 0.744
1yy5 FADPolyamine oxidase FMS1 / 0.743
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.743
2vvl FADMonoamine oxidase N 1.4.3.4 0.742
3lsh FADPyranose 2-oxidase / 0.742
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.741
4fwe FADLysine-specific histone demethylase 1B 1 0.741
4gcm FADThioredoxin reductase 1.8.1.9 0.741
4gut FADLysine-specific histone demethylase 1B 1 0.740
4u2l SFDCholesterol oxidase 1.1.3.6 0.740
2hko FADLysine-specific histone demethylase 1A 1 0.739
4guu FA9Lysine-specific histone demethylase 1B 1 0.739
1b8s FADCholesterol oxidase 1.1.3.6 0.738
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.738
4i58 FADCyclohexylamine Oxidase / 0.738
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.735
2qa1 FADPgaE / 0.735
2jb1 FADL-amino acid oxidase / 0.734
2yg6 FADPutrescine oxidase / 0.734
4c3x FAD3-ketosteroid dehydrogenase / 0.734
3cn8 FADPolyamine oxidase FMS1 / 0.733
3zdn FADMonoamine oxidase N 1.4.3.4 0.733
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.733
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.732
2yg3 FADPutrescine oxidase / 0.731
4gus FADLysine-specific histone demethylase 1B 1 0.730
2gew FADCholesterol oxidase 1.1.3.6 0.729
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.729
4ech FADPolyamine oxidase FMS1 / 0.729
2yg7 FADPutrescine oxidase / 0.728
4dsg FADUncharacterized protein / 0.728
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.727
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.725
3fpz AHZThiamine thiazole synthase / 0.725
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.725
2cul FADGidA-related protein / 0.723
1n4u FAECholesterol oxidase 1.1.3.6 0.722
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.722
3cnj FADCholesterol oxidase 1.1.3.6 0.722
4xwr FADCholesterol oxidase 1.1.3.6 0.722
4mih FADPyranose 2-oxidase 1.1.3.10 0.721
1ijh FADCholesterol oxidase 1.1.3.6 0.720
5l3d FADLysine-specific histone demethylase 1A 1 0.720
2jae FADL-amino acid oxidase / 0.719
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.719
1z6l FADPolyamine oxidase FMS1 / 0.717
3cgb FADCoenzyme A disulfide reductase / 0.717
3qj4 FADRenalase / 0.717
2eq8 FADDihydrolipoyl dehydrogenase / 0.716
2q7v FADThioredoxin reductase / 0.716
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.715
2igo FADPyranose 2-oxidase / 0.715
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.715
5j60 FADThioredoxin reductase / 0.715
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.713
3b6d FAECholesterol oxidase 1.1.3.6 0.712
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.712
1mxt FAECholesterol oxidase 1.1.3.6 0.711
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.711
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.711
4uir FADOleate hydratase 4.2.1.53 0.711
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.710
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.710
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.710
4cnj FADL-amino acid oxidase / 0.708
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.707
2ywl FADThioredoxin reductase related protein / 0.707
1n1p FADCholesterol oxidase 1.1.3.6 0.706
1n4w FADCholesterol oxidase 1.1.3.6 0.706
1xpq FADPolyamine oxidase FMS1 / 0.706
4xxg FADCholesterol oxidase 1.1.3.6 0.706
2bac FADPutative aminooxidase / 0.705
4mo2 FADUDP-galactopyranose mutase / 0.705
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.705
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.704
1b4v FADCholesterol oxidase 1.1.3.6 0.703
3k30 ADPHistamine dehydrogenase / 0.703
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.702
4jnq FDAThioredoxin reductase / 0.702
2b9w FADPutative aminooxidase / 0.700
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.699
2q0k FADThioredoxin reductase 1.8.1.9 0.699
2rgh FADAlpha-Glycerophosphate Oxidase / 0.699
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.699
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.699
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.697
1nhp FADNADH peroxidase 1.11.1.1 0.697
2hqm FADGlutathione reductase 1.8.1.7 0.697
3cgc FADCoenzyme A disulfide reductase / 0.697
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.696
1tdn FADL-amino-acid oxidase 1.4.3.2 0.696
2jb2 FADL-amino acid oxidase / 0.696
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.696
3bi5 FADPolyamine oxidase FMS1 / 0.696
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.696
1cbo FADCholesterol oxidase 1.1.3.6 0.695
2b9y FADPutative aminooxidase / 0.695
2cvj FADThioredoxin reductase related protein / 0.695
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.695
1nhq FADNADH peroxidase 1.11.1.1 0.694
4u2t FADCholesterol oxidase 1.1.3.6 0.694
1tdk FADL-amino-acid oxidase 1.4.3.2 0.691
2eq7 NADDihydrolipoyl dehydrogenase / 0.691
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.691
4x4j FADPutative oxygenase / 0.691
2rab FADGlutathione amide reductase / 0.690
3cnt FADPolyamine oxidase FMS1 / 0.690
3fg2 FADPutative rubredoxin reductase / 0.690
3nlc FADUncharacterized protein / 0.690
3ict FADCoenzyme A disulfide reductase / 0.689
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.688
2r0c FADPutative FAD-monooxygenase / 0.688
2x3n FADProbable FAD-dependent monooxygenase / 0.688
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.686
2a87 FADThioredoxin reductase 1.8.1.9 0.686
3cty FADProbable thioredoxin reductase / 0.686
4eqs FADCoenzyme A disulfide reductase / 0.686
5hxw FADL-amino acid deaminase / 0.686
2npx FADNADH peroxidase 1.11.1.1 0.685
3pl8 FADPyranose 2-oxidase / 0.685
4x9m FADUncharacterized protein MG039 homolog / 0.685
1f8w FADNADH peroxidase 1.11.1.1 0.684
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.684
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.684
5cku FADL-ornithine N(5)-monooxygenase / 0.684
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.684
1n4v FADCholesterol oxidase 1.1.3.6 0.682
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.682
3syi FADSulfide-quinone reductase / 0.682
4mo2 FDAUDP-galactopyranose mutase / 0.682
3t14 FADSulfide-quinone reductase / 0.681
3t2y FADSulfide-quinone reductase / 0.681
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.680
4rek FADCholesterol oxidase 1.1.3.6 0.680
1cc2 FADCholesterol oxidase 1.1.3.6 0.679
3ada NADSubunit alpha of sarocosine oxidase / 0.679
3dme FADPutative conserved exported protein / 0.679
3utf FDAUDP-galactopyranose mutase / 0.679
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.678
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.678
1yqz FADCoenzyme A disulfide reductase / 0.678
3ad9 FADSubunit beta of sarcosine oxidase / 0.678
3cge FADCoenzyme A disulfide reductase / 0.678
3t2k FADSulfide-quinone reductase / 0.678
4x9n FADUncharacterized protein MG039 homolog / 0.678
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.677
3cgd FADCoenzyme A disulfide reductase / 0.677
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.677
1f8r FADL-amino-acid oxidase 1.4.3.2 0.676
1nhr FADNADH peroxidase 1.11.1.1 0.676
2xve FADPutative flavin-containing monooxygenase / 0.676
3k4c FADPyranose 2-oxidase / 0.676
3lsi FADPyranose 2-oxidase / 0.676
3lsm SFDPyranose 2-oxidase / 0.676
4opl FDAConserved Archaeal protein / 0.676
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.675
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.675
4eqx FADCoenzyme A disulfide reductase / 0.675
4fk1 FADPutative thioredoxin reductase / 0.675
1ges FADGlutathione reductase 1.8.1.7 0.674
2ba9 FADPutative aminooxidase / 0.674
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.674
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.674
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.674
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.673
4u8j FDAUDP-galactopyranose mutase / 0.673
4u8k FDAUDP-galactopyranose mutase / 0.673
3kve FADL-amino-acid oxidase / 0.672
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.672
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.671
2xvf FADPutative flavin-containing monooxygenase / 0.671
3f8d FADNADH oxidase/thioredoxin reductase / 0.671
3ukk FDAUDP-galactopyranose mutase / 0.671
3ukl FADUDP-galactopyranose mutase / 0.671
4dsh FDAUncharacterized protein / 0.671
3znp FADD-amino-acid oxidase 1.4.3.3 0.670
4ysh FADGlycine oxidase / 0.670
2whd FADThioredoxin reductase / 0.669
3ukk FADUDP-galactopyranose mutase / 0.669
2bab FADPutative aminooxidase / 0.668
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.668
4at0 FADPossible succinate dehydrogenase / 0.668
1joa FADNADH peroxidase 1.11.1.1 0.667
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.667
2r9z FADGlutathione amide reductase / 0.666
1d7y FADFerredoxin reductase / 0.665
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.665
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.665
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.665
2du8 FADD-amino-acid oxidase 1.4.3.3 0.665
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.665
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.664
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.663
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.663
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.663
3s5w FADL-ornithine N(5)-monooxygenase / 0.663
4eqw FADCoenzyme A disulfide reductase / 0.663
2cdu ADPNADH oxidase / 0.662
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.662
2pd7 FADVivid PAS protein VVD / 0.661
4bjz FADProbable salicylate monooxygenase / 0.661
4eqr FADCoenzyme A disulfide reductase / 0.661
4u8p FDAUDP-galactopyranose mutase / 0.661
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.660
1ojt FADDihydrolipoyl dehydrogenase / 0.660
2gqw FADFerredoxin reductase / 0.660
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.660
2yvj FADFerredoxin reductase / 0.660
3utg FDAUDP-galactopyranose mutase / 0.660
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.659
2gvc FADThiol-specific monooxygenase 1.14.13 0.659
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.659
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.659
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.659
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.659
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.659
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.659
4u8l FDAUDP-galactopyranose mutase / 0.659
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.659
3hdy FDAUDP-galactopyranose mutase / 0.658
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.658
1npx FADNADH peroxidase 1.11.1.1 0.656
1tdo FADL-amino-acid oxidase 1.4.3.2 0.656
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.656
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.656
4nzh FADL-ornithine N(5)-monooxygenase / 0.656
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.655
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.655
4mok FADPyranose 2-oxidase / 0.655
4wx1 FDAUDP-galactopyranose mutase / 0.655
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.655
1tdf FADThioredoxin reductase 1.8.1.9 0.654
2q0l FADThioredoxin reductase 1.8.1.9 0.654
3f8p NADNADH oxidase/thioredoxin reductase / 0.654
4cnk FADL-amino acid oxidase / 0.654
4u8o FDAUDP-galactopyranose mutase / 0.654
1gxf FADTrypanothione reductase 1.8.1.12 0.653
1sez FADProtoporphyrinogen oxidase, mitochondrial 1.3.3.4 0.653
4u8i FDAUDP-galactopyranose mutase / 0.653
3bg7 FADPyranose 2-oxidase / 0.652
2xlp FADPutative flavin-containing monooxygenase / 0.651
3he3 FADUDP-galactopyranose mutase / 0.651
4a65 FADThioredoxin reductase / 0.651
4ccq FADThioredoxin reductase / 0.651
3gwd FADCyclohexanone monooxygenase / 0.650
3hji FADVivid PAS protein VVD / 0.650