Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4yzc STU Serine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 1.146
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.870
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.857
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.827
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.813
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.812
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.812
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.798
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.774
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.764
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.764
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.759
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.757
3dtc VINMitogen-activated protein kinase kinase kinase 9 2.7.11.25 0.756
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.753
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.752
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.744
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.739
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.737
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.725
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.721
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.714
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.706
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.704
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.702
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.700
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.696
1xjd STUProtein kinase C theta type 2.7.11.13 0.695
1wvy STUDeath-associated protein kinase 1 2.7.11.1 0.689
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.688
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.685
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.685
3lcd BDYMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.683
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.675
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.673
1uu7 BI23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660