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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ynm SAM Histone-lysine N-methyltransferase ASH1L 2.1.1.43

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ynm SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 1.047
4ypa SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 1.031
4h12 SAHHistone-lysine N-methyltransferase SETD2 2.1.1.43 0.942
3ooi SAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific 2.1.1.43 0.892
5jhn SAMHistone-lysine N-methyltransferase EHMT2 / 0.890
4ynp SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.861
5jj0 SAMHistone-lysine N-methyltransferase EHMT2 / 0.855
4ypu SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.854
5jin SAMHistone-lysine N-methyltransferase EHMT2 / 0.853
2r3a SAMHistone-lysine N-methyltransferase SUV39H2 2.1.1.43 0.824
2rfi SAHHistone-lysine N-methyltransferase EHMT1 / 0.808
3swc SAHHistone-lysine N-methyltransferase EHMT1 / 0.807
3hna SAHHistone-lysine N-methyltransferase EHMT1 / 0.806
2o8j SAHHistone-lysine N-methyltransferase EHMT2 / 0.801
4z4p SAHHistone-lysine N-methyltransferase 2D 2.1.1.43 0.791
5czy SAMEukaryotic huntingtin interacting protein B / 0.760
2igq SAHHistone-lysine N-methyltransferase EHMT1 / 0.757
4ype SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.743
5f59 SAHHistone-lysine N-methyltransferase 2C 2.1.1.43 0.717
5ex0 SAHHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.702
4bup SAMHistone-lysine N-methyltransferase KMT5B 2.1.1.43 0.695
3qwp SAMHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.685
4o30 SAHProbable Histone-lysine N-methyltransferase ATXR5 2.1.1.43 0.681
4j83 SAMHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.670
3tg4 SAMN-lysine methyltransferase SMYD2 / 0.655