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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4yaf 2AM NADPH--cytochrome P450 reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4yaf 2AMNADPH--cytochrome P450 reductase / 1.062
4yal 2AMNADPH--cytochrome P450 reductase / 1.054
3qft NAPNADPH--cytochrome P450 reductase / 1.035
4yau 2AMNADPH--cytochrome P450 reductase / 1.035
3qfs NAPNADPH--cytochrome P450 reductase / 1.034
4yaw 2AMNADPH--cytochrome P450 reductase / 1.022
3qfc NAPNADPH--cytochrome P450 reductase / 1.009
3qe2 NAPNADPH--cytochrome P450 reductase / 1.002
4y7c NAPNADPH--cytochrome P450 reductase / 0.985
4y9u NAPNADPH--cytochrome P450 reductase / 0.985
4y9r NAPNADPH--cytochrome P450 reductase / 0.948
1ja1 NAPNADPH--cytochrome P450 reductase / 0.943
1amo NAPNADPH--cytochrome P450 reductase / 0.928
1f20 NAPNitric oxide synthase, brain 1.14.13.39 0.919
1ja0 NAPNADPH--cytochrome P450 reductase / 0.908
3qfr NAPNADPH--cytochrome P450 reductase / 0.882
4yao 2AMNADPH--cytochrome P450 reductase / 0.880
3ojx NAPNADPH--cytochrome P450 reductase / 0.870
3zc3 NAPFerredoxin--NADP reductase 1.18.1.2 0.817
1fnd A2PFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.785
2bf4 NAPNADPH--cytochrome P450 reductase / 0.785
1tll NAPNitric oxide synthase, brain 1.14.13.39 0.784
2bpo NAPNADPH--cytochrome P450 reductase / 0.770
1w87 NAPFerredoxin--NADP reductase 1.18.1.2 0.724
2ok7 A2PFerredoxin--NADP reductase, apicoplast / 0.719
2bn4 NAPNADPH--cytochrome P450 reductase / 0.715
1gjr NAPFerredoxin--NADP reductase 1.18.1.2 0.696
2rc6 NAPFerredoxin--NADP reductase / 0.696
3l77 NJPShort-chain alcohol dehydrogenase / 0.681
3p82 FMNPentaerythritol tetranitrate reductase / 0.670
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.665
3lby SAHUncharacterized protein / 0.662
4ag5 ADPType IV secretory pathway VirB4 components-like protein / 0.661
4hwk NAPSepiapterin reductase 1.1.1.153 0.661
4kyh ZSTLactoylglutathione lyase 4.4.1.5 0.660
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.659
1xnj ADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.7.1.25 0.657
4koy CSCUncharacterized protein / 0.657
1bmf ADPATP synthase subunit alpha, mitochondrial / 0.655
1bmf ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.655
1xmv ADPProtein RecA / 0.655
3u9e COALmo1369 protein / 0.655
3wcz NAPAldo-keto reductase AKR2E4 / 0.654
3d8b ADPFidgetin-like protein 1 3.6.4 0.653
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.651
3mle ADPATP-dependent dethiobiotin synthetase BioD 6.3.3.3 0.651
3tif ADPUncharacterized ABC transporter ATP-binding protein MJ0796 / 0.651
2tdm UMPThymidylate synthase / 0.650
3ea5 GDPGTP-binding nuclear protein Ran / 0.650
3g49 NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.650
4ij1 17CAnthranilate phosphoribosyltransferase / 0.650
4rzu ADPProbable thymidylate kinase 2.7.4.9 0.650