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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xt6 NAP Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4xt6 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.969
4xt4 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.863
4xrb NDPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.773
3nxx NDPDihydrofolate reductase 1.5.1.3 0.708
4m6j NDPDihydrofolate reductase 1.5.1.3 0.705
4xt5 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.699
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.698
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.684
1dr5 NAPDihydrofolate reductase 1.5.1.3 0.681
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.674
2cig 1DGDihydrofolate reductase 1.5.1.3 0.670
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.668
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.668
2o7p NAPRiboflavin biosynthesis protein RibD / 0.667
5ecc NAPDehydrofolate reductase type I / 0.661
3qlr NDPDihydrofolate reductase 1.5.1.3 0.659
3qls NDPDihydrofolate reductase 1.5.1.3 0.658
3tqa NDPDihydrofolate reductase / 0.657
1dr3 TAPDihydrofolate reductase 1.5.1.3 0.651
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.650