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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xlv ACP Insulin receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4xlv ACPInsulin receptor 2.7.10.1 1.074
3bu5 ATPInsulin receptor 2.7.10.1 0.918
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.805
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.805
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.794
2pui ADPMethylthioribose kinase 2.7.1.100 0.790
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.784
5dt3 ATPAurora kinase A 2.7.11.1 0.780
4gyi ADPUncharacterized protein / 0.779
1mq4 ADPAurora kinase A 2.7.11.1 0.777
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.773
3cly ACPFibroblast growth factor receptor 2 / 0.771
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.768
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.766
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.763
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.762
4ceg ADPAurora kinase A 2.7.11.1 0.761
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.758
4dee ADPAurora kinase A 2.7.11.1 0.758
5eg3 ACPFibroblast growth factor receptor 2 / 0.758
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.754
4utd ACPAurora kinase A 2.7.11.1 0.754
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.754
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.753
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.751
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.751
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.751
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.749
2pun ACPMethylthioribose kinase 2.7.1.100 0.747
5ce3 ADPProtein kinase YopO / 0.747
2pzp ACPFibroblast growth factor receptor 2 / 0.746
5dt4 ATPAurora kinase A 2.7.11.1 0.746
1cm8 ANPMitogen-activated protein kinase 12 / 0.745
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.745
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.744
2olc ADPMethylthioribose kinase 2.7.1.100 0.744
4qny ANPMitogen activated protein kinase, putative / 0.744
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.743
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.741
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.740
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.740
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.739
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.739
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.738
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.738
3c4z ADPRhodopsin kinase / 0.737
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.735
5dos ATPAurora kinase A 2.7.11.1 0.735
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.733
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.732
5dn3 ATPAurora kinase A 2.7.11.1 0.732
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.730
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.729
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.728
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.728
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.726
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.726
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.725
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.725
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.725
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.725
2pul ACPMethylthioribose kinase 2.7.1.100 0.723
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.722
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.721
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.721
3wo1 ADPAlanine--anticapsin ligase / 0.721
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.720
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.720
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.720
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.719
4bn1 ADPAurora kinase A 2.7.11.1 0.719
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.717
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.717
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.716
2pz5 ACPFibroblast growth factor receptor 2 / 0.716
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.715
5iqe GNPBifunctional AAC/APH 2.3.1 0.715
2dwb ANPAurora kinase A 2.7.11.1 0.714
3rv4 ADPBiotin carboxylase 6.3.4.14 0.714
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.714
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.713
5iqa GNPBifunctional AAC/APH 2.3.1 0.712
3c50 ADPRhodopsin kinase / 0.711
4o4f ATPKinase / 0.710
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.710
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.709
4o4e ATPKinase / 0.709
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.709
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.708
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.707
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.707
2py3 ACPFibroblast growth factor receptor 2 / 0.707
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.707
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.707
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.705
3t8o ATPRhodopsin kinase / 0.704
1ol5 ADPAurora kinase A 2.7.11.1 0.703
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.703
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.703
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.701
5dnr ATPAurora kinase A 2.7.11.1 0.701
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.700
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.700
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.699
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.698
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.698
4c3r ACPAurora kinase A 2.7.11.1 0.698
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.697
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.697
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.696
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.696
2pup ADPMethylthioribose kinase 2.7.1.100 0.695
4o1p ANPRibonuclease L / 0.695
5drd ATPAurora kinase A 2.7.11.1 0.695
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.694
2pml ANPUncharacterized protein / 0.694
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.694
3pff ADPATP-citrate synthase 2.3.3.8 0.694
5dr2 ATPAurora kinase A 2.7.11.1 0.694
5iqi GNPBifunctional AAC/APH 2.3.1 0.694
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.693
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.693
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.693
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.692
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.691
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.691
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.691
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.690
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
2p0a ANPSynapsin-3 / 0.689
3tw6 ADPPyruvate carboxylase / 0.689
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.689
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.689
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.688
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.688
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.688
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.686
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.686
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4ysj ADPCalmodulin-like domain protein kinase / 0.686
2j9g ADPBiotin carboxylase 6.3.4.14 0.685
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.685
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.685
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.684
3c4w ATPRhodopsin kinase / 0.684
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.684
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.684
4ffm ADPUncharacterized protein / 0.683
4ix5 ANPUncharacterized protein / 0.683
1i44 ACPInsulin receptor 2.7.10.1 0.682
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.682
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.681
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.681
2pyw ADPMethylthioribose kinase 2.7.1.100 0.680
3nie ANPMitogen-activated protein kinase / 0.680
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.680
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.680
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.679
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.679
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
5iqd GNPBifunctional AAC/APH 2.3.1 0.679
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.678
2g2f AGSTyrosine-protein kinase ABL1 2.7.10.2 0.677
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.677
3q5i ANPProtein kinase, putative / 0.677
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.676
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.676
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
1ir3 ANPInsulin receptor 2.7.10.1 0.674
2vqd AP2Biotin carboxylase 6.3.4.14 0.674
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.674
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.672
3ori AGSSerine/threonine protein kinase / 0.672
3oro AGSSerine/threonine protein kinase / 0.672
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.672
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.671
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.671
1rfu ADPPyridoxal kinase 2.7.1.35 0.670
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.670
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.670
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.670
1ol6 ATPAurora kinase A 2.7.11.1 0.669
2yaa ATPDeath-associated protein kinase 2 / 0.669
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.669
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.669
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.668
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.666
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.666
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.666
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.666
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.665
4o4d ATPKinase / 0.665
5byl GCPBifunctional AAC/APH 2.3.1 0.665
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.664
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.662
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.662
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
3orm AGSSerine/threonine protein kinase / 0.662
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.661
5iqb GNPBifunctional AAC/APH 2.3.1 0.661
2zdg ADPD-alanine--D-alanine ligase / 0.660
4c3p ACPAurora kinase A 2.7.11.1 0.660
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.660
1kh3 ANPArgininosuccinate synthase / 0.659
5jr3 SAHCarminomycin 4-O-methyltransferase DnrK 2.1.1.292 0.659
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.658
3qc9 ADPRhodopsin kinase / 0.658
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.658
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.658
4xfj ANPArgininosuccinate synthase / 0.658
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.657
4bw9 ANPPyrrolysine--tRNA ligase / 0.657
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.657
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.656
2cjm ATPCyclin-dependent kinase 2 2.7.11.22 0.656
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.656
3ort AGSSerine/threonine protein kinase / 0.655
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.655
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.654
2pbz ATPUncharacterized protein / 0.654
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.654
4rr7 A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.654
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
5iqf GDPBifunctional AAC/APH 2.3.1 0.654
2ozo ANPTyrosine-protein kinase ZAP-70 2.7.10.2 0.653
1u54 ACPActivated CDC42 kinase 1 / 0.652
2cch ATPCyclin-dependent kinase 2 2.7.11.22 0.652
3s87 ADPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.652
4ag5 ADPType IV secretory pathway VirB4 components-like protein / 0.652
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.652
1m0w ANPGlutathione synthetase 6.3.2.3 0.651
3orp AGSSerine/threonine protein kinase / 0.651
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.651
2wtk ANPSTE20-related kinase adapter protein alpha / 0.650
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.650
3llt ANPProtein serine/threonine kinase-1 / 0.650