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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xfj ANP Argininosuccinate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4xfj ANPArgininosuccinate synthase / 1.059
1kp2 ATPArgininosuccinate synthase 6.3.4.5 0.771
1kh2 ATPArgininosuccinate synthase / 0.729
1kh3 ANPArgininosuccinate synthase / 0.722
4fak SAMRibosomal RNA large subunit methyltransferase H / 0.715
4pzk SAHPutative tRNA (cytidine(34)-2'-O)-methyltransferase / 0.703
4cng SAHSpoU rRNA methylase / 0.691
1mbz IOTCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.689
2cx8 SAHRibosomal RNA small subunit methyltransferase E / 0.688
4x3l MTARNA 2'-O ribose methyltransferase / 0.688
2egw SAHRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.683
4cnf MTASpoU rRNA methylase / 0.682
3sl2 ATPSensor histidine kinase WalK / 0.679
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.677
3o7b SAHRibosomal RNA small subunit methyltransferase Nep1 / 0.676
4biw ANPSensor histidine kinase CpxA / 0.676
3oii SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.673
1mb9 ATPCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.670
2npn SAMPutative cobalamin synthesis related protein / 0.670
1ih8 APCNH(3)-dependent NAD(+) synthetase 6.3.1.5 0.669
3t10 ACPHeat shock protein HSP 90-alpha / 0.668
1mxi SAHtRNA (cytidine(34)-2'-O)-methyltransferase / 0.667
3rk1 ATPN-type ATP pyrophosphatase superfamily / 0.665
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.662
1kor ANPArgininosuccinate synthase / 0.661
4kgn SAHtRNA (cytidine(34)-2'-O)-methyltransferase / 0.658
4xlv ACPInsulin receptor 2.7.10.1 0.658
1j1z ATPArgininosuccinate synthase / 0.656
2hma SAMtRNA-specific 2-thiouridylase MnmA / 0.654
4bwa N0BPyrrolysine--tRNA ligase / 0.654
4xbo SAHtRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ 2.1.1.200 0.654
4pl9 ADPEthylene receptor 1 / 0.653
5ahw CMPUniversal stress protein family protein, putative / 0.653
1cbf SAHCobalt-precorrin-4 C(11)-methyltransferase 2.1.1.271 0.652
2pz8 APCNH(3)-dependent NAD(+) synthetase / 0.652
2z08 ATPUniversal stress protein family / 0.652
4dca ADPAminoglycoside phosphotransferase / 0.652
2ybo SAHMethyltransferase / 0.651
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.651
4xc0 ACPHeat shock cognate 90 kDa protein / 0.651