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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4x6r ATP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.269
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.044
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.024
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.018
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.008
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.008
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.994
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.988
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.975
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.975
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.974
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.956
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.945
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.941
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.938
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.926
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.923
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.921
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.895
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.892
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.892
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.888
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.873
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.870
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.856
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.844
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.844
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.842
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.835
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.831
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.796
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.787
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.780
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.778
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.775
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.773
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.773
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.772
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.765
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.765
4ysj ADPCalmodulin-like domain protein kinase / 0.764
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.761
1cm8 ANPMitogen-activated protein kinase 12 / 0.752
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.751
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.750
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.750
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.749
3ori AGSSerine/threonine protein kinase / 0.746
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.744
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.743
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.742
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.741
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.741
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.740
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.738
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.737
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.736
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.735
2pml ANPUncharacterized protein / 0.732
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.732
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.729
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.724
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.723
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.722
5ce3 ADPProtein kinase YopO / 0.722
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.721
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.720
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.717
5dn3 ATPAurora kinase A 2.7.11.1 0.715
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.714
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.714
3orm AGSSerine/threonine protein kinase / 0.713
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.713
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.713
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.712
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.710
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.708
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.707
5dt3 ATPAurora kinase A 2.7.11.1 0.707
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.705
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.705
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.704
4dee ADPAurora kinase A 2.7.11.1 0.703
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.702
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.701
4qny ANPMitogen activated protein kinase, putative / 0.700
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.700
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.699
3rv4 ADPBiotin carboxylase 6.3.4.14 0.699
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.699
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.698
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.697
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.696
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.693
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.692
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.692
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.692
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.691
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.689
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.689
1ol6 ATPAurora kinase A 2.7.11.1 0.687
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.687
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.685
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.685
4utd ACPAurora kinase A 2.7.11.1 0.683
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.682
4ceg ADPAurora kinase A 2.7.11.1 0.681
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.681
3c4z ADPRhodopsin kinase / 0.679
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.678
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.678
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.676
3qc9 ADPRhodopsin kinase / 0.676
5iqb GNPBifunctional AAC/APH 2.3.1 0.675
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.674
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.674
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.674
1ol5 ADPAurora kinase A 2.7.11.1 0.672
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.672
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.671
5dos ATPAurora kinase A 2.7.11.1 0.671
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.670
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.669
2vqd AP2Biotin carboxylase 6.3.4.14 0.669
2wqe ADPAurora kinase A 2.7.11.1 0.669
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.669
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.669
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.669
5dr2 ATPAurora kinase A 2.7.11.1 0.669
5eg3 ACPFibroblast growth factor receptor 2 / 0.669
2x86 ADPADP-L-glycero-D-manno-heptose-6-epimerase / 0.667
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.667
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.667
3t8o ATPRhodopsin kinase / 0.666
4o0w ADNAurora kinase A 2.7.11.1 0.666
2yaa ATPDeath-associated protein kinase 2 / 0.665
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.665
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.664
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.664
5dnr ATPAurora kinase A 2.7.11.1 0.664
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.663
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.662
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.662
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.661
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.661
4to4 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.661
2pul ACPMethylthioribose kinase 2.7.1.100 0.660
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.660
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.659
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.659
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.659
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.659
3g8c ADPBiotin carboxylase 6.3.4.14 0.658
3g8d ADPBiotin carboxylase 6.3.4.14 0.658
4o1p ANPRibonuclease L / 0.658
4yxs EMUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.657
2pz5 ACPFibroblast growth factor receptor 2 / 0.657
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.657
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.657
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.657
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.657
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.656
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.655
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.655
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.655
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.654
1os1 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.653
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.653
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.653
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.653
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.652
3nie ANPMitogen-activated protein kinase / 0.652
3oro AGSSerine/threonine protein kinase / 0.652
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.652
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.651
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.650